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首页> 美国卫生研究院文献>Asian Journal of Andrology >Apogossypolone a novel inhibitor of antiapoptotic Bcl-2 family proteins induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro
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Apogossypolone a novel inhibitor of antiapoptotic Bcl-2 family proteins induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro

机译：Apogossypolone一种抗凋亡Bcl-2家族蛋白的新型抑制剂在体外诱导PC-3和LNCaP前列腺癌细胞的自噬。

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Limited treatment options are available for aggressive prostate cancer. Gossypol has been reported to have a potent anticancer activity in many types of cancer. It can increase the sensitivity of cancer cells to alkylating agents, diminish multidrug resistance and decrease metastasis. Whether or not it can induce autophagy in cancer cells has not yet been determined. Here we investigated the antiproliferative activity of apogossypolone (ApoG2) and (−)-gossypol on the human prostate cancer cell line PC3 and LNCaP in vitro. Exposure of PC-3 and LNCaP cells to ApoG2 resulted in several specific features characteristic of autophagy, including the appearance of membranous vacuoles in the cytoplasm and formation of acidic vesicular organelles. Expression of autophagy-associated LC3-II and beclin-1 increased in both cell lines after treatment. Inhibition of autophagy with 3-methyladenine promoted apoptosis of both cell types. Taken together, these data demonstrated that induction of autophagy could represent a defense mechanism against apoptosis in human prostate cancer cells.
机译：侵袭性前列腺癌的治疗方法有限。据报道，棉酚在许多类型的癌症中均具有有效的抗癌活性。它可以增加癌细胞对烷基化剂的敏感性，减少多药耐药性并减少转移。它是否可以诱导癌细胞自噬尚未确定。在这里，我们研究了载脂孢子酮（ApoG2）和（-）-棉酚在体外对人前列腺癌细胞系PC3和LNCaP的抗增殖活性。 PC-3和LNCaP细胞暴露于ApoG2导致自噬的几个特定特征，包括在细胞质中出现膜性液泡和形成酸性水泡细胞器。处理后，两种细胞系中自噬相关的LC3-II和beclin-1的表达均增加。用3-甲基腺嘌呤抑制自噬可促进两种细胞的凋亡。综上所述，这些数据表明自噬的诱导可以代表针对人类前列腺癌细胞凋亡的防御机制。

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