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The reliability of height and height velocity in the assessment of growth (the Wessex Growth Study)

机译:身高和身高速度在生长评估中的可靠性(韦塞克斯生长研究)

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摘要

Both biochemical and auxological measurements can be used to assess growth. Quality control in routinely reported in laboratory studies, but the reproducibility of height measurements, and the height velocity data derived from them, is seldom considered. We have previously established our error and in this report we examine its implications for the screening of short children and subsequent monitoring of their growth. The 95% confidence interval for height for a 5 year old observed to be on the 3rd centile for height, spanned the 2nd-4th centile. However, the confidence interval for a 12 month height velocity appropriate to such a child spanned the 8th-52nd centiles, the lower limit pathological and the upper more than satisfactory. A single height velocity even over 12 months therefore lacks the precision to provide a reliable index of current growth in short children. Furthermore, serial height velocity calculations on a cohort of 78 short normal children showed no significant correlation from year to year, suggesting that velocity is also unable to predict future growth. Although the proportion of this cohort of short children lying beneath the 25th centile for velocity remained constant from year to year, the identity of the individuals comprising that proportion changed, a phenomenon which could be largely accounted for by the random error associated with height velocity. Our data suggest that, by the time a trend in abnormal velocity is reliably established, a deviation from the height centiles is clearly evident. Although velocity charts are attractive in concept, they seem to be no more discriminating than height charts in practice, and may be clinically deceptive unless interpreted with great care.
机译:生化测量和生理学测量均可用于评估生长。在实验室研究中常规报告了质量控制,但是很少考虑高度测量的可重复性以及从中得出的高度速度数据。我们先前已经确定了错误,在本报告中,我们研究了其对筛选矮个子及其后监测其生长的影响。 5岁儿童身高的95%置信区间位于身高的第3个百分位,跨越第2个至第4个百分位。但是,适合这种儿童的12个月身高速度的置信区间跨越8至52个百分位,病理的下限和上限都令人满意。因此,即使超过12个月,单身的身高速度也缺乏为矮个子的孩子提供可靠的当前生长指标的精度。此外,对一组78名正常的矮小正常儿童的连续身高速度计算,每年之间均无显着相关性,这表明速度也无法预测未来的增长。尽管这批矮子儿童的速度在每年25岁以下的比例每年都保持不变,但构成这一比例的个体的身份却发生了变化,这一现象在很大程度上可以归因于与身高速度相关的随机误差。我们的数据表明,当可靠地确定异常速度的趋势时,与高度百分位数的偏差就很明显了。尽管速度图在概念上很有吸引力,但在实践中它们似乎并没有比高度图更具区分性,并且除非特别注意,否则可能具有临床欺骗性。

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