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首页> 美国卫生研究院文献>Antimicrobial Agents and Chemotherapy >Comparative susceptibilities of Pseudomonas aeruginosa to 1-oxacephalosporin (LY 127935) and eight other antipseudomonal antimicrobial agents (old and new).
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Comparative susceptibilities of Pseudomonas aeruginosa to 1-oxacephalosporin (LY 127935) and eight other antipseudomonal antimicrobial agents (old and new).

机译：铜绿假单胞菌对1-oxacephalosporin（LY 127935）和其他八种抗伪伪抗菌剂（新旧）的比较敏感性。

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摘要

In vitro susceptibilities of 53 clinical isolates of Pseudomonas aeruginosa to nine antipseudomonal antibiotics were determined. From 96 to 100% of the isolates were susceptible to piperacillin, ticarcillin, and 1-oxacephalosporin (LY 127935). Of the aminoglycosides, 89, 82, 79, and 29% were susceptible to amikacin, tobramycin, gentamicin, and netilmicin, respectively. A total of 96% and 78% of the isolates were susceptible to 1-oxacephalosporin (LY127935) and cefotaxime, respectively, at concentrations of 62.5 micrograms/l. Supplementation of testing media by calcium and magnesium not only markedly increased the minimal inhibitory concentrations of the aminoglycosides, but also raised those of cefotaxime and the penicillins; no significant effect was noted with 1-oxace-phalosporin. Synergy was not demonstrated consistently in vitro with 1-oxace-phalosporin combined with either carbenicillin, ticarcillin, gentamicin, or tobramycin.
机译：测定了53株铜绿假单胞菌临床分离株对9种抗假单胞菌抗生素的体外敏感性。 96％至100％的分离株对哌拉西林，替卡西林和1-oxacephalosporin（LY 127935）敏感。在氨基糖苷类中，分别有89％，82％，79％和29％易受阿米卡星，妥布霉素，庆大霉素和奈替米星的影响。分别有62.5微克/升的浓度，分别有96％和78％的分离株对1-oxacephalosporin（LY127935）和头孢噻肟敏感。用钙和镁补充测试培养基不仅显着提高了氨基糖苷的最低抑菌浓度，而且还提高了头孢噻肟和青霉素的抑菌浓度。 1-oxace-phalosporin没有明显的作用。 1-氧acepha-phalosporin与羧苄青霉素，替卡西林，庆大霉素或妥布霉素的体外协同作用未得到一致证实。

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