首页> 美国卫生研究院文献>Antimicrobial Agents and Chemotherapy >Ribavirin antagonizes inhibitory effects of pyrimidine 23-dideoxynucleosides but enhances inhibitory effects of purine 23-dideoxynucleosides on replication of human immunodeficiency virus in vitro.

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Ribavirin antagonizes inhibitory effects of pyrimidine 23-dideoxynucleosides but enhances inhibitory effects of purine 23-dideoxynucleosides on replication of human immunodeficiency virus in vitro.

机译：利巴韦林拮抗嘧啶23-双脱氧核苷的抑制作用但增强嘌呤23-双脱氧核苷对体外人免疫缺陷病毒复制的抑制作用。

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摘要

The combined antiviral effects of various 2',3'-dideoxynucleosides and ribavirin on the replication of human immunodeficiency virus type 1 in MT-4 cells have been examined. Ribavirin antagonized the antiviral activity of the pyrimidine 2',3'-dideoxynucleosides (3'-azido-2',3'-dideoxythymidine, 2',3'-dideoxythymidin-2'-ene, 2',3'-dideoxycytidine, and 2',3'-dideoxycytidin-2'-ene), but enhanced the antiviral activity of the purine 2',3'-dideoxynucleosides (2',3'-dideoxyadenosine and 2',3'-dideoxyguanosine). Combinations of the 2',3'-dideoxynucleosides with each other were also examined. These combinations resulted in an additive to subsynergistic effect.

机译：已经检查了各种2'，3'-二脱氧核苷和利巴韦林对MT-4细胞中1型人类免疫缺陷病毒复制的联合抗病毒作用。利巴韦林拮抗嘧啶2'，3'-二脱氧核苷（3'-叠氮基2'，3'-二脱氧胸苷，2'，3'-二脱氧胸苷2'-烯，2'，3'-二脱氧胞苷，和2'，3'-二脱氧胞苷-2'-烯），但增强了嘌呤2'，3'-二脱氧核苷（2'，3'-二脱氧腺苷和2'，3'-二脱氧鸟苷）的抗病毒活性。还检查了2'，3'-二脱氧核苷的相互结合。这些组合导致亚协同效应的加和。

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
M Baba; R Pauwels; J Balzarini; P Herdewijn; E De Clercq; J Desmyter;
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作者单位

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年(卷),期 1987(31),10
年度 1987
页码 1613–1617
总页数 5
原文格式 PDF
正文语种
中图分类药学;微生物学;
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1. In Vitro Inhibitory Effects of the Herbal-Marine Compound HESA-A Against Replication of Human Immunodeficiency Virus-1 [J] . Aghasadeghi MohammadReza, Ahmadi Amrollah, Amini Safieh, Jundishapur Journal of Microbiology . 2012,第1期

机译：草药-海洋化合物HESA-A对人免疫缺陷病毒-1复制的体外抑制作用。
2. Inhibitory effects of small-molecule CCR5 antagonists on human immunodeficiency virus type 1 envelope-mediated membrane fusion and viral replication. [J] . Takashima K, Miyake H, Furuta RA, Antimicrobial agents and chemotherapy. . 2001,第12期

机译：小分子CCR5拮抗剂对人免疫缺陷病毒1型包膜介导的膜融合和病毒复制的抑制作用。
3. Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. [J] . Harmsen MC, Swart PJ, de Bethune MP, The Journal of Infectious Diseases . 1995,第2期

机译：血浆和乳蛋白的抗病毒作用：乳铁蛋白在体外对人免疫缺陷病毒和人巨细胞病毒复制均显示有效的活性。
4. Characterization of Cucurbitane Glycosides from the Fruit of Momordica grosvenori with LCMS and Their Inhibitory Effects on Epstein-Barr Virus Activation [C] . Naoto Shimizu, Toshihiro Akihisa, Hiroki Kumagai, ASMS Conference on Mass Spectrometry and Allied Topics . 2007

机译：用LCMS与LCMS果实果实果蝇的表征及其对Epstein-Barr病毒激活的抑制作用
5. The effects of insulin and insulin-like growth factor-I on the replication of the human immunodeficiency virus type 1 in vitro. [D] . DeSantis, Teresa Anna. 1994

机译：胰岛素和胰岛素样生长因子-I对人免疫缺陷病毒1型体外复制的影响。
6. Disparate actions of hydroxyurea in potentiation of purine and pyrimidine 23-dideoxynucleoside activities against replication of human immunodeficiency virus. [O] . W Y Gao, D G Johns, S Chokekuchai, 1995

机译：羟基脲在嘌呤和嘧啶23-二脱氧核苷活性增强中对人类免疫缺陷病毒复制的作用不同。
7. Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro. [O] . Baba, M, Pauwels, R, Balzarini, J, 1987

机译：利巴韦林拮抗嘧啶2'，3'-双脱氧核苷的抑制作用，但增强嘌呤2'，3'-双脱氧核苷对体外人免疫缺陷病毒复制的抑制作用。

Ribavirin antagonizes inhibitory effects of pyrimidine 23-dideoxynucleosides but enhances inhibitory effects of purine 23-dideoxynucleosides on replication of human immunodeficiency virus in vitro.

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