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首页> 美国卫生研究院文献>Antimicrobial Agents and Chemotherapy >Increased sensitivity of Candida albicans cells accumulating 14 alpha-methylated sterols to active oxygen: possible relevance to in vivo efficacies of azole antifungal agents.
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Increased sensitivity of Candida albicans cells accumulating 14 alpha-methylated sterols to active oxygen: possible relevance to in vivo efficacies of azole antifungal agents.

机译：积聚14种α-甲基化固醇的白色念珠菌细胞对活性氧的敏感性增加：可能与唑类抗真菌剂的体内功效有关。

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The sensitivity of Candida albicans cells to killing by hydrogen peroxide was found to increase markedly when they were grown in the presence of sub-growth-inhibitory concentrations of the azole drug clotrimazole (CTZ). A superoxide anion-generating system consisting of xanthine and xanthine oxidase also killed such CTZ-treated cells more efficiently than control cells, but this seemed to be accounted for by hydrogen peroxide secondarily formed from superoxide anion as judged by the effect of catalase and superoxide dismutase. The increased sensitivity to hydrogen peroxide was considered to be attributable to the inhibition of 14 alpha-demethylation of ergosterol biosynthesis by CTZ, since a 14 alpha-demethylation-deficient mutant of C. albicans exhibited a similar phenotype. It is suggested that the in vivo efficacy of azole antifungal agents against C. albicans infection is at least partially due to the sensitization of the fungal cells to the oxygen-dependent microbicidal system of the phagocyte.
机译：发现白色念珠菌细胞在亚生长抑制浓度的唑类药物克霉唑（CTZ）存在下生长时，对过氧化氢杀伤的敏感性显着提高。由黄嘌呤和黄嘌呤氧化酶组成的超氧化物阴离子产生系统也比对照细胞更有效地杀死了这种经CTZ处理的细胞，但这似乎是由过氧化氢继而形成的过氧化氢所致，这是由过氧化氢酶和超氧化物歧化酶的作用所判断的。 。对过氧化氢的敏感性增加被认为归因于CTZ对麦角固醇生物合成的14α-脱甲基的抑制，因为白色念珠菌的14α-脱甲基缺失的突变体表现出相似的表型。提示唑类抗真菌剂对白色念珠菌感染的体内功效至少部分是由于真菌细胞对吞噬细胞的氧依赖性杀微生物系统的敏感性所致。

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