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首页> 美国卫生研究院文献>Antimicrobial Agents and Chemotherapy >Establishment of a Superficial Skin Infection Model in Mice by Using Staphylococcus aureus and Streptococcus pyogenes
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Establishment of a Superficial Skin Infection Model in Mice by Using Staphylococcus aureus and Streptococcus pyogenes

机译：利用金黄色葡萄球菌和化脓性链球菌建立小鼠浅表皮肤感染模型

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摘要

A new animal model for the purpose of studying superficial infections is presented. In this model an infection is established by disruption of the skin barrier by partial removal of the epidermal layer by tape stripping and subsequent application of the pathogens Staphylococcus aureus and Streptococcus pyogenes. The infection and the infection route are purely topical, in contrast to those used in previously described animal models in mice, such as the skin suture-wound model, where the infection is introduced into the deeper layers of the skin. Thus, the present model is considered more biologically relevant for the study of superficial skin infections in mice and humans. Established topical antibiotic treatments are shown to be effective. The procedures involved in the model are simple, a feature that increases throughput and reproducibility. This new model should be applicable to the evaluation of novel antimicrobial treatments of superficial infections caused by S. aureus and S. pyogenes.
机译：为了研究浅表感染，提出了一种新的动物模型。在该模型中，通过胶带剥离部分去除表皮层并随后施加病原体金黄色葡萄球菌和化脓性链球菌破坏皮肤屏障，从而建立感染。与先前在小鼠中描述的动物模型（例如皮肤缝合伤口模型）中使用的那些模型不同，感染和感染途径纯粹是局部的，其中将感染引入皮肤的更深层。因此，本模型被认为与研究小鼠和人类的浅表皮肤感染在生物学上更相关。建立的局部抗生素治疗被证明是有效的。模型中涉及的过程很简单，此功能可提高吞吐量和可重复性。该新模型应适用于评估由金黄色葡萄球菌和化脓性链球菌引起的浅表感染的新型抗菌治疗。

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