• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Annals of Surgery >Metabolic utilization of intravenous fat emulsion during total parenteral nutrition.
【2h】

Metabolic utilization of intravenous fat emulsion during total parenteral nutrition.

机译：全胃肠外营养期间静脉脂肪乳剂的代谢利用。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effect of nutritional therapy on the utilization of an intravenous fat emulsion was studied in patients with injury, infection, and nutritional depletion using I-14C-trioleate labeled Intralipid. The plasma fractional removal rate and 14C-Intralipid oxidation rate was 55% ad 25% higher, respectively, in patients following trauma and during periods of infection receiving 5% dextrose than in healthy control subjects. Total parenteral nutrition (TPN) was administered as either 1) nonprotein calories given as glucose (Glucose System) or 2) equal proportions of glucose and intravenous fat emulsion (Lipid System). In comparison to TPN with the Lipid System, administration using the Glucose System resulted in higher plasma clearance rates and lower oxidation rates in both acutely ill and depleted patients. There was no correlation between the rates of plasma removal and oxidation of the intravenous fat emulsion (r = -0.04; NS) indicating that the removal of exogenous fat from plasma cannot be used as an indicator of oxidation. A negative linear relationship was seen between the oxidation rate of intravenous fat and carbohydrate intake (r = -0.92; p less than 0.001). Glucose intakes exceeding energy expenditure did not totally inhibit oxidation of the fat emulsion. The oxidation rate of 14C-Intralipid was linearly related to net whole body fat oxidation calculated using indirect calorimetry (r = -0.90; p less than 0.001) suggesting that the fat emulsion was oxidized in a similar manner to endogenous lipids. This study suggests that intravenous fat emulsions are utilized as an energy substrate in patients with major injury, infection or nutritional depletion. This observation, along with a relative unresponsiveness to glucose in surgical patients suggests that fat emulsions may be useful as a calorie source in patients receiving parenteral nutrition.
机译：使用I-14C-三油酸酯标记的Intralipidid对受伤，感染和营养耗竭的患者进行了营养疗法对静脉脂肪乳利用的影响研究。与健康对照组相比，创伤后患者和感染期间接受5％葡萄糖的患者血浆分数去除率和14C-脂质内氧化率分别提高55％和25％。总肠胃外营养（TPN）是以1）以葡萄糖给出的非蛋白质卡路里（葡萄糖系统）或2）等比例的葡萄糖和静脉内脂肪乳剂（Lipid System）的形式施用的。与使用脂质系统的TPN相比，使用葡萄糖系统进行给药的急性病患者和贫血患者的血浆清除率更高，氧化率更低。血浆脂肪清除率与静脉内脂肪乳剂的氧化速率之间无相关性（r = -0.04； NS），表明血浆中外源脂肪的去除不能用作氧化指标。静脉内脂肪的氧化速率与碳水化合物摄入之间存在负线性关系（r = -0.92； p小于0.001）。超过能量消耗的葡萄糖摄入不能完全抑制脂肪乳剂的氧化。 14C-Intralipid的氧化速率与使用间接量热法计算得出的全身总净脂肪氧化线性相关（r = -0.90； p小于0.001），表明脂肪乳状液以与内源脂质相似的方式被氧化。这项研究表明，静脉内脂肪乳剂可作为严重损伤，感染或营养不良患者的能量底物。该观察结果以及外科患者对葡萄糖的相对无反应性表明，脂肪乳剂可能在接受肠胃外营养的患者中用作卡路里来源。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号