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首页> 美国卫生研究院文献>Annals of Surgery >The prognostic significance of preoperative carcinoembryonic antigen levels in colorectal cancer. Results from NSABP (National Surgical Adjuvant Breast and Bowel Project) clinical trials.
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The prognostic significance of preoperative carcinoembryonic antigen levels in colorectal cancer. Results from NSABP (National Surgical Adjuvant Breast and Bowel Project) clinical trials.

机译：术前癌胚抗原水平在大肠癌中的预后意义。 NSABP（国家外科手术辅助乳房和肠项目）临床试验的结果。

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This analysis explores the prognostic significance of preoperative carcinoembryonic antigen (CEA) levels in patients with colorectal cancer. The data were derived from 945 patients entered into two randomized prospective clinical trials of the National Surgical Adjuvant Breast and Bowel Project. A strong correlation was evident between preoperative CEA level and Dukes class. The mean CEA progressively increased with each Dukes category and the mean value for each of the four classes was significantly different. This relationship was prevalent whether the data were analyzed for all colorectal lesions regardless of location or specifically for right-sided colon tumors. The prognostic function of preoperative CEA level was independent of the number of positive histologic nodes. Preoperative CEA level correlated with the degree of lumen encirclement by tumor. Tumors that did not encircle more than one half the lumen were associated with significantly lower preoperative CEA levels than those that did. The presence or absence of lumen obstruction was unrelated to the preoperative CEA level. The relative risk of developing a treatment failure was associated with preoperative CEA, in both Dukes B and C patients, demonstrating that the prognostic significance of preoperative CEA was independent of Dukes class.
机译：该分析探讨了大肠癌患者术前癌胚抗原（CEA）水平的预后意义。数据来自945名患者，这些患者参加了国家外科手术辅助乳房和肠项目的两项随机前瞻性临床试验。术前CEA水平与Dukes级别之间存在明显的相关性。每个Dukes类别的平均CEA逐渐增加，四个类别的平均值均显着不同。无论是否分析所有大肠病变的数据，无论其位置如何，还是专门针对右侧结肠肿瘤，这种关系都是普遍存在的。术前CEA水平的预后功能与阳性组织学淋巴结数目无关。术前CEA水平与肿瘤管腔包围程度有关。包围腔不超过一半的肿瘤与术前CEA水平明显降低有关。管腔阻塞的存在与否与术前CEA水平无关。在Dukes B和C患者中，发生治疗失败的相对风险与术前CEA相关，表明术前CEA的预后意义与Dukes类无关。

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