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首页> 美国卫生研究院文献>Annals of the Rheumatic Diseases >Acute abdominal pain in systemic lupus erythematosus: focus on lupus enteritis (gastrointestinal vasculitis)
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Acute abdominal pain in systemic lupus erythematosus: focus on lupus enteritis (gastrointestinal vasculitis)

机译：系统性红斑狼疮的急性腹痛：以狼疮性肠炎（胃肠道血管炎）为重点

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Methods: A retrospective study was carried out for all patients admitted with SLE from 1993 to March 2001. The SLEDAI and laboratory data were collected at the time of diagnosis of SLE and at the time of acute abdominal pain. Lupus enteritis (gastrointestinal vasculitis) was diagnosed by clinical investigation and abdominal computed tomographic findings. Results: Chart review identified 175 patients (20 male, 155 female) who had been admitted with SLE. Of these patients, 38 (22%) presented with acute abdominal pain. Lupus enteritis was the most common cause of acute abdominal pain. Patients were divided into three groups: group 1: lupus enteritis (n=17), group 2: acute abdominal pain without lupus enteritis (n=21), and group 3: SLE without acute abdominal pain (n=137). There was no difference in age and sex among the three groups. Antiphospholipid, anti-RNP, anti-Sm, anti-Ro, and anti-La antibodies did not differ among the three groups. There was no difference in the SLEDAI at the time of diagnosis and at the time of acute abdominal pain between groups 1 and 2. Complement, erythrocyte sedimentation rate, C reactive protein, and anti-dsDNA measured at the time of acute abdominal pain did not differ between groups 1 and 2. A drop in the white blood cell count at the time of abdominal pain was more prominent in group 1 than group 2. In lupus enteritis, the jejunum and ileum were the sites most commonly affected. Rectal involvement was rare. Even though four patients relapsed, all the patients with lupus enteritis, including those who relapsed, responded well to corticosteroid. Conclusion: Lupus enteritis is the most common cause of acute abdominal pain in SLE. All patients with lupus enteritis responded well to a high dose of a corticosteroid without surgical intervention. The SLEDAI and laboratory data, except leucopenia, do not correlate with the occurrence of lupus enteritis.
机译：方法：对1993年至2001年3月收治的所有SLE患者进行回顾性研究。在SLE诊断时和急性腹痛时收集SLEDAI和实验室数据。狼疮性肠炎（胃肠道血管炎）通过临床调查和腹部CT表现诊断出来。结果：图表审查确定了175例SLE患者（男性20例，女性155例）。在这些患者中，有38名（22％）出现了急性腹痛。狼疮性肠炎是急性腹痛的最常见原因。患者分为三组：第1组：狼疮性肠炎（n = 17），第2组：无狼疮性肠炎的急性腹痛（n = 21），第3组：无急性腹痛的SLE（n = 137）。三组之间在年龄和性别上没有差异。三组之间的抗磷脂，抗RNP，抗Sm，抗Ro和抗La抗体没有差异。第1组和第2组在诊断时和急性腹痛时的SLEDAI无差异。在急性腹痛时测得的补体，红细胞沉降率，C反应蛋白和抗dsDNA均无差异。第1组和第2组之间的差异。与第2组相比，第1组中腹痛时白细胞计数下降更为明显。在狼疮性肠炎中，空肠和回肠是最常见的部位。直肠受累少见。即使四名患者复发，所有狼疮性肠炎患者（包括复发者）对皮质类固醇的反应也很好。结论：狼疮性肠炎是SLE急性腹痛的最常见原因。所有狼疮性肠炎患者对高剂量的皮质类固醇激素反应良好，无需手术干预。除白细胞减少症外，SLEDAI和实验室数据与狼疮性肠炎的发生无关。

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