• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Annals of the Rheumatic Diseases >Outcome of a cohort of 300 patients with systemic lupus erythematosus attending a dedicated clinic for over two decades
【2h】

Outcome of a cohort of 300 patients with systemic lupus erythematosus attending a dedicated clinic for over two decades

机译：300名系统性红斑狼疮患者的队列研究结果超过二十年

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To examine the mortality rate and causes of death in a cohort of 300 patients with systemic lupus erythematosus (SLE). Methods: A retrospective analysis was performed on all patients attending the SLE clinic between 1978 and 2000. Information was obtained on those patients lost to follow up. Cause of death was analysed and categorised as early (<5 years after diagnosis of SLE) and late (>5 years after diagnosis of SLE). Standardised mortality rates were obtained. Results: The patients were followed up for a median of 8.3 years. Seventy three (24%) patients were no longer followed up at the end of the study period, of whom 41 (14%) had died. Of the 32 patients lost to follow up, 14 were being actively followed up within the UK, 16 were followed up outside the UK, and two patients were untraceable. The most common cause of death was malignancy, which accounted for eight (20%) deaths, followed by infection and vascular disease, which accounted for seven (17%) deaths each. Conclusions: Malignancy was the most common cause of death. Cause of death varied depending on disease duration. Forty per cent of early deaths were due to SLE related renal disease, whereas 23% of late deaths were due to vascular causes. Death due to infection occurred throughout the follow up period. There was a fourfold increased risk of death in our cohort of patients with SLE compared with the general population.
机译：目的：探讨300例系统性红斑狼疮（SLE）患者的死亡率和死亡原因。方法：对1978年至2000年间所有参加SLE诊所的患者进行回顾性分析。获得了有关失访患者的信息。分析死亡原因，并将其分类为早期（诊断为SLE后<5年）和晚期（诊断为SLE后> 5年）。获得标准化死亡率。结果：对患者进行了平均8。3年的随访。在研究期结束时不再对73位患者（24％）进行随访，其中41位（14％）死亡。在失去随访的32例患者中，有14例在英国进行了积极的随访，有16例在英国境外进行了随访，有2例患者无法追踪。最常见的死亡原因是恶性肿瘤，其导致八人（20％）死亡，其次是感染和血管疾病，其分别导致七人（17％）死亡。结论：恶性肿瘤是最常见的死亡原因。死亡原因取决于疾病持续时间。早期死亡的40％是由于SLE相关的肾脏疾病，而晚期死亡的23％是由于血管原因。在整个随访期间都发生了因感染导致的死亡。与普通人群相比，我们队列中的SLE患者死亡风险增加了四倍。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号