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首页> 美国卫生研究院文献>Annals of the Rheumatic Diseases >Influence of HLA polymorphism on persistent remission in rheumatoid arthritis
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Influence of HLA polymorphism on persistent remission in rheumatoid arthritis

机译：HLA多态性对类风湿关节炎持续缓解的影响

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Objective: To determine the distribution of HLA-DRB1 and DQB1/DQA1 alleles in a cohort of patients with RA in remission and to determine the association between these HLA alleles and the persistence of remission. Patients and methods: HLA-DRB1 and DQB1 typings were performed in 167 patients with RA in remission, defined according to the American College of Rheumatology criteria. The disease course, as defined by the persistence of remission during a follow up of two years, was compared between subgroups. According to the RAP hypothesis patients were divided into three subgroups: patients carrying predisposing DQ alleles, patients carrying predisposing alleles in combination with protective alleles (DQRA+/DERAA phenotype), and patients lacking the predisposing alleles. According to the SE hypothesis, patients were divided into three subgroups based on whether they were carrying two, one, or no predisposing alleles (SE alleles). Results: Predisposing DQ alleles along with a DERAA-bearing allele were present in 14 (8%) of the 167 patients. At least one SE allele was present in 116 (69%) patients; 34 of them (20%) were carrying two copies. The disease course was not significantly different between the subgroups according to the SE and RAP hypothesis, respectively. Conclusion: The frequency of DQRA+/DERAA combinations and of SE alleles in patients with RA clinically in remission was similar to that found in other RA populations. Persistent remission of RA was not associated with any particular HLA subtypes, indicating that HLA typing is not useful for predicting persistent clinical remission.
机译：目的：确定HLA-DRB1和DQB1 / DQA1等位基因在RA缓解期患者队列中的分布，并确定这些HLA等位基因与缓解持续时间之间的关联。患者和方法：根据美国风湿病学会标准对167例缓解期RA患者进行了HLA-DRB1和DQB1分型。在亚组之间比较了根据两年随访期间持续缓解所定义的疾病进程。根据RAP假设，将患者分为三个亚组：携带易感DQ等位基因的患者，携带易感等位基因与保护性等位基因（DQ RA + / DERAA表型）的患者和缺乏易感等位基因的患者。根据SE假设，根据患者携带的是两个，一个或没有易感等位基因（SE等位基因）将其分为三个亚组。结果：167例患者中有14例（8％）存在易感DQ等位基因和DERAA携带等位基因。 116名（69％）患者中至少存在一种SE等位基因；其中34人（20％）携带两本。分别根据SE和RAP假设，亚组之间的疾病进程无显着差异。结论：临床缓解的RA患者中DQ RA + / DERAA组合和SE等位基因的频率与其他RA人群相似。 RA的持续缓解与任何特定的HLA亚型均不相关，这表明HLA分型对于预测持续的临床缓解没有用。

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