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首页> 美国卫生研究院文献>Annals of Medicine and Surgery >Water in the human body: An anesthesiologists perspective on the connection between physicochemical properties of water and physiologic relevance
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Water in the human body: An anesthesiologists perspective on the connection between physicochemical properties of water and physiologic relevance

机译：人体中的水：麻醉师对水的物理化学性质与生理相关性之间联系的看法

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摘要

The unique structure and multifaceted physicochemical properties of the water molecule, in addition to its universal presence in body compartments, make water a key player in multiple biological processes in human physiology. Since anesthesiologists deal with physiologic processes where water molecules are critical at different levels, and administer medications whose pharmacokinetics and pharmacodynamics depend on interaction with water molecules, we consider that exploration of basic science aspects related to water and its role in physiology and pharmacology is relevant to the practice of anesthesiology. The purpose of this paper is to delineate the physicochemical basis of water that are critical in enabling it to support various homeostatic processes. The role of water in the formation of solutions, modulation of surface tension and in homeostasis of body temperature, acid-base status and osmolarity, is analyzed. Relevance of molecular water interactions to the anesthesiologist is not limited to the realm of physiology and pathophysiology. Deep knowledge of the importance of water in volatile anesthetic effects on neurons opens a window to a new comprehensive understanding of complex cellular mechanisms underlying the practice of anesthesiology.
机译：水分子的独特结构和多方面的理化特性，除了在人体隔室中的普遍存在外，还使水成为人类生理学中多个生物学过程的关键参与者。由于麻醉学家处理水分子在不同水平上至关重要的生理过程，并管理药代动力学和药效学依赖于与水分子相互作用的药物，因此我们认为探索与水有关的基础科学及其在生理学和药理学中的作用与麻醉学的实践。本文的目的是描述水的物理化学基础，这对于使水能够支持各种稳态过程至关重要。分析了水在溶液形成，表面张力调节以及体温，酸碱状态和渗透压体内稳态中的作用。分子水相互作用与麻醉师的相关性不限于生理学和病理生理学领域。对水在对神经元的挥发性麻醉作用中的重要性的深入了解为全面全面了解麻醉实践基础的复杂细胞机制打开了一个窗口。

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