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Comparison of Capillary Electrophoresis with Cellulose Acetate Electrophoresis for the Screening of Hemoglobinopathies

机译:毛细管电泳与醋酸纤维素电泳筛查血红蛋白病的比较

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摘要

Backgroundβ-thalassemia is primarily found in individuals of Mediterranean and Southeast Asian ancestry. With rapid growth in the Southeast Asian segments of the Korean population, the geographic distribution of hemoglobinopathies is expected to become significantly different from what it is today. In this study, Hb fractions were measured in patients with hypochromic microcytosis to detect thalassemia and Hb variants. To evaluate the feasibility of replacing cellulose acetate electrophoresis (CA) with capillary electrophoresis (CE) in a clinical laboratory, both techniques were performed and the outcomes were compared.
机译:背景β地中海贫血主要存在于地中海和东南亚血统的个体中。随着韩国人口东南亚地区的快速增长,预计血红蛋白病的地理分布将与今天的状况发生显着变化。在这项研究中,对血红蛋白缺乏症患者的Hb分数进行了检测,以检测地中海贫血和Hb变异体。为了评估在临床实验室中用毛细管电泳(CE)代替醋酸纤维素电泳(CA)的可行性,两种技术均进行了比较,并对结果进行了比较。

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