首页> 美国卫生研究院文献>The American Journal of Tropical Medicine and Hygiene >Divergent Effects of Schistosoma haematobium Exposure on Intermediate-Host Snail Species Bulinus nasutus and Bulinus globosus from Coastal Kenya
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Divergent Effects of Schistosoma haematobium Exposure on Intermediate-Host Snail Species Bulinus nasutus and Bulinus globosus from Coastal Kenya

机译:血吸虫血吸虫病对肯尼亚沿海沿岸蜗牛中间种Bulinus nasutus和Bulinus globosus的不同影响

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摘要

Schistosoma haematobium infection causes urogenital schistosomiasis, a chronic inflammatory disease that is highly prevalent in many parts of sub-Saharan Africa. Bulinid snails are the obligate intermediate hosts in the transmission of this parasite. In the present study, Bulinus globosus and Bulinus nasutus snails from coastal Kenya were raised in the laboratory and exposed to miracidia derived from sympatric S. haematobium specimens to assess the species-specific impact of parasite contact and infection. The snails' subsequent patterns of survival, cercarial shedding, and reproduction were monitored for up to 3 months postexposure. Schistosoma haematobium exposure significantly decreased the survival of B. globosus, but not of B. nasutus. Although both species were capable of transmitting S. haematobium, the B. globosus study population had a greater cumulative incidence of cercarial shedders and a higher average number of cercariae shed per snail than did the B. nasutus population. The effects of prior parasite exposure on snail reproduction were different between the two species. These included more numerous production of egg masses by exposed B. nasutus (as compared with unexposed snails), contrasted to decreased overall egg mass production by parasite-exposed B. globosus. The interspecies differences in the response to and transmission of S. haematobium reflect clear differences in life histories for the two bulinid species when they interact with the parasite, which should be taken into account when planning control interventions aimed at reducing each host snails' contribution to local transmission of Schistosoma infection.
机译:血吸虫血吸虫感染会导致泌尿生殖道血吸虫病,这是一种慢性炎症性疾病,在撒哈拉以南非洲的许多地区非常普遍。钉螺是该寄生虫传播的专性中间宿主。在本研究中,在实验室中饲养了来自肯尼亚沿海的球孢和田螺,并将其暴露于源自同胞血球菌标本的水病,以评估寄生虫接触和感染对物种的特定影响。暴露后长达3个月的时间,监测蜗牛的存活,子宫颈脱落和繁殖的规律。血吸虫血吸虫接触显着降低了球形双歧杆菌的存活,但没有降低纳豆双歧杆菌的存活。尽管这两个物种都能够传播血红球菌,但比纳索氏菌种群,球芽孢杆菌研究人群的每只蜗牛脱落的累积发生率更高,平均每只蜗牛的尾c脱落数量也更高。先前的寄生虫接触对蜗牛繁殖的影响在两个物种之间是不同的。这些包括通过暴露的纳豆芽孢杆菌产生的大量蛋块(与未暴露的蜗牛相比),与通过寄生虫暴露的球芽孢杆菌降低的总体卵块产量相反。种对沙门氏菌的反应和传播的种间差异反映了两种藻类与寄生虫相互作用时其生活史的明显差异,在计划旨在减少每只寄主蜗牛对螺的贡献的控制干预措施时应考虑这些差异。血吸虫感染的局部传播。

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