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Inflammatory bowel disease related innate immunity and adaptive immunity

机译:炎症性肠病与先天免疫和适应性免疫有关

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摘要

Inflammatory bowel disease (IBD) is a chronic nonspecific intestinal inflammatory disease, including ulcerative colitis (UC) and Crohn’s disease (CD). Its pathogenesis remains not yet clear. Current researchers believe that after environmental factors act on individuals with genetic susceptibility, an abnormal intestinal immune response is launched under stimulation of intestinal flora. However, previous studies only focused on adaptive immunity in the pathogenesis of IBD. Currently, roles of innate immune response in the pathogenesis of intestinal inflammation have also drawn much attention. In this study, IBD related innate immunity and adaptive immunity were explained, especially the immune mechanisms in the pathogenesis of IBD.
机译:炎性肠病(IBD)是一种慢性非特异性肠道炎性疾病,包括溃疡性结肠炎(UC)和克罗恩氏病(CD)。其发病机理仍不清楚。当前的研究人员认为,在环境因素对具有遗传易感性的个体起作用之后,在肠道菌群的刺激下会引发异常的肠道免疫反应。然而,先前的研究仅关注IBD发病机理中的适应性免疫。当前,先天免疫应答在肠道炎症的发病机理中的作用也引起了广泛关注。在这项研究中,解释了IBD相关的先天免疫和适应性免疫,尤其是IBD发病机理中的免疫机制。

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