首页> 美国卫生研究院文献>Thorax >Intravascular haemolysis after valve replacement: comparative study between Starr-Edwards (ball valve) and Björk-Shiley (disc valve) prosthesis.
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Intravascular haemolysis after valve replacement: comparative study between Starr-Edwards (ball valve) and Björk-Shiley (disc valve) prosthesis.

机译:瓣膜置换术后血管内溶血:Starr-Edwards(球形瓣膜)和Björk-Shiley(碟形瓣膜)假体之间的比较研究。

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摘要

Seventy-four patients with single prosthetic valves (Björk-Shiley or Starr-Edwards) in the mitral or aortic position and 18 controls with rheumatic valvar heart disease were investigated for evidence of intravascular haemolysis. Serum lactate dehydrogenase (LDH) was used as the most sensitive indicator of haemolysis. Raised concentrations were found in a third of 39 patients with Björk-Shiley prostheses (mean 281 IU/l) and in all 35 patients with Starr-Edwards prostheses (mean 859 IU/l. Values were considerably higher in patients with Starr-Edwards prostheses and particularly in those with aortic prostheses (mean 927 IU/l). Eight out of 12 patients with haemosiderinuria had Starr-Edwards valves. Intravascular haemolysis was of little clinical significance in patients with Björk-Shiley prostheses, but some patients with Starr-Edwards prostheses became iron deficient as a result.
机译:研究了二尖瓣或主动脉位的单瓣人工瓣膜患者(Björk-Shiley或Starr-Edwards)和风湿性瓣膜性心脏病的18名对照的74例患者的血管内溶血证据。血清乳酸脱氢酶(LDH)被用作溶血的最敏感指标。在39例Björk-Shiley假体患者中发现浓度升高(平均281 IU / l),在所有35例Starr-Edwards假体患者中发现浓度升高(平均859 IU / l)。Starr-Edwards假体患者的值明显更高特别是在那些主动脉假体患者(平均927 IU / l)中,每12名血尿蛋白尿患者中有8名具有Starr-Edwards瓣膜;对Björk-Shiley假体患者,血管内溶血的临床意义不大,但有些患者具有Starr-Edwards假体结果,假肢变得缺铁。

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