HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees.

机译：HLA和多发性硬化症的遗传：72个家系的连锁分析。

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Linkage analysis of 72 pedigrees by the maximum-likelihood method provides evidence of linkage between HLA and the hypothesized multiple sclerosis susceptibility gene (MSSG) for both the dominant and recessive models of inheritance and for penetrance values ranging from 5%--65% (or higher). This MSSG, if it exists, is most likely located at 15%--20% recombination units from the HLA complex, probably on the B-D side. The analysis also shows that there is no heterogeneity in the estimates of linkage, and lod scores are not artifically inflated because of the association of multiple sclerosis (MS) with HLA-B7.

机译：通过最大似然法对72个家谱进行连锁分析，为显性遗传和隐性遗传模型以及5％至5％（或-5％）外显率值的HLA与假设的多发性硬化易感基因（MSSG）之间的关联提供了证据更高）。该MSSG（如果存在）最有可能位于HLA复合体的15％-20％重组单元，可能在B-D侧。分析还表明，在连锁估计中没有异质性，并且由于多发性硬化症（MS）与HLA-B7的关联，lod得分没有被人为夸大。

著录项

期刊名称 American Journal of Human Genetics
作者
J L Tiwari; S E Hodge; P I Terasaki; M A Spence;
展开▼
作者单位

展开▼
年(卷),期 1980(32),1
年度 1980
页码 103–111
总页数 9
原文格式 PDF
正文语种
中图分类遗传学;
关键词

相似文献

外文文献
中文文献
专利

1. Linkage analysis conditional on HLA status in a large North American pedigree supports the presence of a multiple sclerosis susceptibility locus on chromosome 12p12. [J] . Vitale E, Cook S, Sun R, Human Molecular Genetics . 2002,第3期

机译：北美大谱系中以HLA状态为条件的连锁分析支持在12p12号染色体上存在多发性硬化易感性基因座。
2. The co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region alone. [J] . Marrosu MG, Motzo C, Murru R, Human Molecular Genetics . 2004,第23期

机译：撒丁岛1型糖尿病和多发性硬化症的共同遗传不能仅通过HLA地区的基因型变异来解释。
3. Inheritance mode of multiple sclerosis: the effect of HLA class II alleles is stronger than additive. [J] . Boon M, Nolte IM, De Keyser J, Human Genetics . 2004,第4期

机译：多发性硬化症的遗传方式：HLA II类等位基因的作用强于累加性。
4. HLA Analysis and Disease for Multiple Sclerosis [C] . Hsin-Wen Tsao, Hung-Wen Chiu European Conference of the International Federation for Medical and Biological Engineering . 2013

机译：多发性硬化症的HLA分析和疾病
5. Covariate based linkage analysis and linkage disequilibrium mapping in the HLA region for inflammatory bowel disease. [D] . Doan, Betty Quynh-Huong. 2005

机译：HLA区域中基于协变量的连锁分析和连锁不平衡图分析，用于炎症性肠病。
6. Family Analysis of Linkage and Association of HLA-DRB1 CTLA4 TGFB1 IL4 CCR5 RANTES MMP9 and TIMP1 Gene Polymorphisms with Multiple Sclerosis [O] . O.Yu. Makarycheva, E.Yu. Tsareva, M.A. Sudomoina, 2011

机译：HLA-DRB1CTLA4TGFB1IL4CCR5RANTESMMP9和TIMP1基因多态性与多发性硬化的联系和关联的家族分析
7. Linkage analysis conditional on HLA status in a large North American pedigree supports the presence of a multiple sclerosis susceptibility locus on chromosome 12p12 [O] . E. Vitale 2002

机译：LINKAGE分析在大型北美谱系中的HLA状态下的条件支持染色体12P12上的多发性硬化敏感性座位

HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees.

摘要

著录项

相似文献

相关主题

期刊订阅