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Phadiatop Seropositivity in Schizophrenia Patients and Controls: A Preliminary Study

机译：精神分裂症患者和对照的Phadiatop血清阳性：初步研究

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There is a dearth of information on the association of atopy with schizophrenia. The few available studies used population-based registers to classify the atopy status of the patients but this strategy is not reliable. This study measured seropositivity with a multiallergen screen of allergen specific IgE antibodies in schizophrenia patients versus healthy controls. A subset of 66 schizophrenia patients and 34 healthy controls were randomly selected from a large comparative study of schizophrenia patients and controls. The Phadiatop multi-allergen screen was performed on sera from all the participants to assess their atopic status. Logistic regression was used to calculate the odds ratio for the association of schizophrenia with Phadiatop seropositivity as a measure of atopy. The prevalence of Phadiatop seropositivity was significantly lower (χ2 4.59, p = 0.032) and there was a reduced odds ratio for atopy in schizophrenia patients relative to controls (OR 0.40; 95% CI 0.17 to 0.94, p = 0.036). Though limited by a relatively small sample size and potentially confounded by anti-psychotic medications, this study suggests that the prevalence of atopy is lower in patients with schizophrenia. Replicating these results in larger samples could add to our growing understanding of immunological implications in mental illness.
机译：缺乏关于特应性与精神分裂症的关联的信息。很少有可用的研究使用基于人群的登记簿对患者的特应性状态进行分类，但是这种策略并不可靠。这项研究通过多变应原筛查的精神分裂症患者与健康对照者的变应原特异性IgE抗体，测量了血清阳性。从大型的精神分裂症患者和对照比较研究中随机选择66位精神分裂症患者和34个健康对照的子集。对所有参与者的血清进行Phadiatop多变应原筛查，以评估他们的特应性状况。使用Logistic回归来计算精神分裂症与Phadiatop血清阳性的关联的比值比，作为特应性的度量。与精神分裂症患者相比，精神分裂症患者的Phadiatop血清阳性阳性率显着较低（χ 2 4.59，p = 0.032），异位症的优势比降低（OR 0.40; 95％CI 0.17至0.94， p = 0.036）。尽管受到相对较小的样本量的限制，并且可能会与抗精神病药物混淆，但这项研究表明，精神分裂症患者中特应性的患病率较低。将这些结果复制到更大的样本中可能会增加我们对精神疾病中免疫学意义的认识。

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