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首页> 美国卫生研究院文献>Aging (Albany NY) >Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time
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Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time

机译：复制性衰老人类细胞具有昼夜节律的改变具有延长的时间和延迟的峰值时间

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Over the last decade, a wide array of evidence has been accumulated that disruption of circadian clock is prone to cause age-related diseases and premature aging. On the other hand, aging has been identified as one of the risk factors linked to the alteration of circadian clock. These evidences suggest that the processes of aging and circadian clock feedback on each other at the animal level. However, at the cellular level, we recently revealed that the primary fibroblast cells derived from Bmal1-/- mouse embryo, in which circadian clock is completely disrupted, do not demonstrate the acceleration of cellular aging, i.e., cellular senescence. In addition, little is known about the impact of cellular senescence on circadian clock. In this study, we show for the first time that senescent cells possess a longer circadian period with delayed peak-time and that the variability in peak-time is wider in the senescent cells compared to their proliferative counterparts, indicating that senescent cells show alterations of circadian clock. We, furthermore, propose that investigation at cellular level is a powerful and useful approach to dissect molecular mechanisms of aging in the circadian clock.
机译：在过去的十年中，已经积累了大量证据，证明昼夜节律的破坏很容易引起与年龄有关的疾病和过早衰老。另一方面，衰老已被确定为与昼夜节律改变有关的危险因素之一。这些证据表明衰老过程和生物钟在动物水平上相互反馈。然而，在细胞水平上，我们最近发现，从昼夜节律完全被破坏的Bmal1 -/-小鼠胚胎衍生的原代成纤维细胞不能证明细胞衰老加速，即细胞衰老。此外，关于细胞衰老对生物钟的影响知之甚少。在这项研究中，我们首次显示了衰老细胞具有较长的昼夜节律周期，且峰时间延迟，并且衰老细胞中峰时间的变异性大于增殖细胞，这表明衰老细胞表现出细胞凋亡的变化。昼夜节律时钟。我们还建议，在细胞水平上进行研究是剖析昼夜节律中衰老的分子机制的一种强大而有用的方法。

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