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首页> 美国卫生研究院文献>Advances in Nutrition >Comparative Metabolic Physiology in the ‘omics’ Era: A Call to Arms Paws Flippers and Claws
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Comparative Metabolic Physiology in the ‘omics’ Era: A Call to Arms Paws Flippers and Claws

机译：组学时代的新陈代谢生理学：对手臂爪子脚蹼和爪子的呼唤

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摘要

In nutrition, medicine, and animal science, metabolism research is often focused on solving questions using a single organism. Outcomes are most often linked to translational outcomes, understanding or treating a disease, optimizing nutritional status, improving select qualities of production animals, which have tremendous value to human and animal health as well as economic benefit. There is also value in clarifying basic biological principles and integrative systems that determine how organisms function and deal with their environment. Relevant to both translational and basic research questions, comparative metabolic physiology provides a context by which new “omics” technologies and other approaches can be coupled to multi-species metabolic phenotype diversity. These principles were highlighted at the “Adipose and Lipid Biology: Crossing Taxonomic Boundaries” symposium held at the 2013 Experimental Biology meeting in Boston, MA. By considering differences and shared physiology across a spectrum of phenotypes (especially when considering “extremes” that have emerged from evolutionary processes or breeding selection), one may unmask subtle processes and learn from natural adaptations.
机译：在营养，医学和动物科学中，新陈代谢研究通常集中于使用单一生物体解决问题。结果通常与翻译结果，了解或治疗疾病，优化营养状况，提高生产动物的精选品质有关，这对人类和动物健康以及经济利益均具有巨大价值。阐明确定生物体如何运作和处理其环境的基本生物学原理和整合系统也具有价值。与翻译和基础研究问题相关，比较代谢生理学为新的“组学”技术和其他方法与多物种代谢表型多样性耦合提供了一个背景。在马萨诸塞州波士顿举行的2013年实验生物学会议上举行的“脂肪和脂类生物学：跨越分类学界限”专题讨论会上强调了这些原则。通过考虑各种表型之间的差异和共同的生理学（尤其是考虑到进化过程或育种选择中出现的“极端”）时，人们可能会掩盖微妙的过程并从自然适应中学习。

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