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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Maternal Pre-Pregnancy Cardiovascular Risk Factors and Offspring and Grandoffspring Health: Bogalusa Daughters
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Maternal Pre-Pregnancy Cardiovascular Risk Factors and Offspring and Grandoffspring Health: Bogalusa Daughters

机译：孕前孕妇的心血管危险因素与后代和后代的健康：Bogalusa女儿

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摘要

Both maternal pre-pregnancy body mass index (BMI) and gestational weight gain have been associated with cardiovascular health in the offspring beyond two generations. A total of 274 daughters (aged 12–54) of 208 mothers who participated in the Bogalusa Heart Study were interviewed about their reproductive history. Mothers’ data was taken from the original study, and cardiovascular measures at the visit prior to pregnancy were correlated with daughter’s measures. Maternal pre-pregnancy BMI, skinfold, and waist circumference were examined as a predictor of daughters’ blood pressure, lipids, and glucose, as well as a predictor of birthweight and gestational age of grandchildren. Maternal pre-pregnancy BMI was associated with higher blood pressure and lower low-density lipoprotein (LDL) and cholesterol in the daughters. Most maternal cardiometabolic risk factors were not associated with grandchildren’s birth outcomes, even though higher cholesterol and LDL was associated with lower gestational age, and higher BMI and skinfold thickness with an increased risk of preterm birth. In this pilot study, some associations were found between maternal adiposity and cardiovascular risk, daughters’ cardiovascular risk, and grandchild birth outcomes. Lack of conclusive associations could be due to a true lack of effect, effects being primarily mediated through daughter’s BMI, or the low power of the study.
机译：孕产妇的体重指数（BMI）和妊娠期体重增加都与后代两代以上的心血管健康有关。参加Bogalusa心脏研究的208名母亲中，共有274名女儿（12-54岁）接受了有关其生殖史的采访。母亲的数据来自原始研究，怀孕前就诊时的心血管测量值与女儿的测量值相关。检查了孕妇的孕前BMI，皮肤皱褶和腰围，以预测女儿的血压，脂质和葡萄糖，并预测其子孙的体重和胎龄。孕妇的孕前BMI与女儿的血压升高，低密度脂蛋白（LDL）和胆固醇降低有关。尽管胆固醇和低密度脂蛋白与较低的胎龄，高体重指数和皮褶厚度增加以及早产风险增加有关，但大多数母亲的心脏代谢危险因素与孙子女的出生结局无关。在这项先导研究中，发现孕妇肥胖与心血管疾病风险，女儿的心血管疾病风险与孙子出生结局之间存在某些关联。缺乏结论性关联的原因可能是由于确实缺乏效果，效果主要是通过女儿的BMI介导的，或者是这项研究的功效较低。

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