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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >A Physiologically-Based Pharmacokinetic Modeling Approach Using Biomonitoring Data in Order to Assess the Contribution of Drinking Water for the Achievement of an Optimal Fluoride Dose for Dental Health in Children
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A Physiologically-Based Pharmacokinetic Modeling Approach Using Biomonitoring Data in Order to Assess the Contribution of Drinking Water for the Achievement of an Optimal Fluoride Dose for Dental Health in Children

机译：一种基于生理学的药代动力学建模方法使用生物监测数据来评估饮用水对实现儿童牙齿健康最佳氟化物剂量的贡献

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Due to an optimal fluoride concentration in drinking water advised for caries prevention purposes, the population is now exposed to multiple sources of fluoride. The availability of population biomonitoring data currently allow us to evaluate the magnitude of this exposure. The objective of this work was, therefore, to use such data in order to estimate whether community water fluoridation still represents a significant contribution toward achieving a suggested daily optimal fluoride (external) intake of 0.05 mg/kg/day. Therefore, a physiologically-based pharmacokinetic model for fluoride published in the literature was used and adapted in Excel for a typical 4-year-old and 8-year-old child. Biomonitoring data from the Canadian Health Measures Survey among people living in provinces with very different drinking water fluoridation coverage (Quebec, 2.5%; Ontario, 70% of the population) were analyzed using this adapted model. Absorbed doses for the 4-year-old and 8-year-old children were, respectively, 0.03 mg/kg/day and 0.02 mg/kg/day in Quebec and of 0.06 mg/kg/day and 0.05 mg/kg/day in Ontario. These results show that community water fluoridation contributes to increased fluoride intake among children, which leads to reaching, and in some cases even exceeding, the suggested optimal absorbed dose of 0.04 mg/kg/day, which corresponds to the suggested optimal fluoride intake mentioned above. In conclusion, this study constitutes an incentive to further explore the multiple sources of fluoride intake and suggests that a new balance between them including drinking water should be examined in accordance with the age-related physiological differences that influence fluoride metabolism.
机译：由于建议用于预防龋齿的饮用水中的最佳氟化物浓度，该人群现在暴露于多种氟化物源。人口生物监测数据的可用性目前使我们能够评估这种暴露的程度。因此，这项工作的目的是使用这些数据来估计社区水的氟化是否仍对实现建议的0.05毫克/千克/天的每日最佳氟化物（外部）摄入量做出重大贡献。因此，使用了文献中公开的基于生理的氟化物药代动力学模型，并在Excel中对典型的4岁和8岁儿童进行了调整。使用这种改编的模型分析了来自加拿大卫生措施调查的生物监测数据，这些人生活在饮用水氟化物覆盖率差异很大的省份中（魁北克，2.5％；安大略，人口的70％）。在魁北克，四岁和八岁儿童的吸收剂量分别为0.03 mg / kg /天和0.02 mg / kg /天，0.06 mg / kg /天和0.05 mg / kg /天在安大略省。这些结果表明，社区水氟化导致儿童氟化物摄入增加，导致达到甚至在某些情况下超过建议的最佳吸收剂量0.04 mg / kg / day，这与上述建议的最佳氟化物摄入量相对应。 。总之，这项研究构成了进一步探索氟化物摄入的多种来源的诱因，并建议应根据影响氟化物代谢的与年龄相关的生理差异，研究包括饮用水在内的多种来源之间的新平衡。

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