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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >The Effects of Hydration Status on Cognitive Performances among Young Adults in Hebei China: A Randomized Controlled Trial (RCT)
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The Effects of Hydration Status on Cognitive Performances among Young Adults in Hebei China: A Randomized Controlled Trial (RCT)

机译：水合状况对河北省青年成年人认知能力的影响：随机对照试验（RCT）

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Background: Dehydration may affect cognitive performances as water accounts for 75% of brain mass. The purpose of this study is to investigate the effects of dehydration and water supplementation on cognitive performances, and to explore the changes of brain structures and functions using MRI. Methods and Analysis: A double-blinded randomized controlled trial has been designed and will be implemented among 64 college students aged 18–23 years from Baoding, China. Subjects will be asked to restrict water for 36 h. The first morning urine will be collected and urine osmolality measured. The fasting blood samples will be collected and osmolality and copeptin will be measured. Three MRI sequences, including fMRI, ASL and 3D BRAVO will be taken to observe the changes of whole brain volume, ventricular volume, BOLD response and the cortex thickness. Cognitive performances and mood will be performed with software and questionnaires, respectively. Subjects in the water supplementation groups 1, 2, 3 will drink 200, 500 and 1000 mL of water, respectively, while subjects in the no water supplementation group will not drink any water. After 90 min, urine and blood samples, MRI scans, cognitive performances and mood will be performed. One-way ANOVA will be used to study the differences among groups. Ethics and Dissemination: The study protocol has been approved by the Peking University Institutional Review Committee. Ethical approval project identification code is IRB00001052-16071. Results will be published according to the CONSORT statement and will be reported in peer-reviewed journals.
机译：背景：脱水可能影响认知能力，因为水占大脑质量的75％。这项研究的目的是研究脱水和补水对认知能力的影响，并使用MRI探索大脑结构和功能的变化。方法和分析：设计了一项双盲随机对照试验，该试验将在来自中国保定的64位18-23岁的大学生中实施。受试者将被要求禁水36小时。第一个早晨将收集尿液并测量尿渗透压。空腹血样将被收集，重量克分子渗透压浓度和肽素将被测量。将采取三个MRI序列，包括fMRI，ASL和3D BRAVO，以观察全脑体积，心室体积，BOLD反应和皮质厚度的变化。认知表现和情绪将分别通过软件和问卷进行。补水组1、2、3中的受试者分别喝200、500和1000 mL的水，而无补水组中的受试者则不喝水。 90分钟后，将进行尿液和血液样本，MRI扫描，认知表现和情绪。单向方差分析将用于研究组之间的差异。伦理与传播：研究方案已获得北京大学机构审查委员会的批准。道德批准项目标识代码为IRB00001052-16071。结果将根据CONSORT声明发布，并在同行评审的期刊中进行报告。

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