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首页> 美国卫生研究院文献>Frontiers in Public Health >The MOBI-Kids Study Protocol: Challenges in Assessing Childhood and Adolescent Exposure to Electromagnetic Fields from Wireless Telecommunication Technologies and Possible Association with Brain Tumor Risk
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The MOBI-Kids Study Protocol: Challenges in Assessing Childhood and Adolescent Exposure to Electromagnetic Fields from Wireless Telecommunication Technologies and Possible Association with Brain Tumor Risk

机译：MOBI-Kids研究方案：评估儿童和青少年从无线通信技术到电磁场的挑战以及可能与脑肿瘤风险的关联

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The rapid increase in mobile phone use in young people has generated concern about possible health effects of exposure to radiofrequency (RF) and extremely low frequency (ELF) electromagnetic fields (EMF). MOBI-Kids, a multinational case–control study, investigates the potential effects of childhood and adolescent exposure to EMF from mobile communications technologies on brain tumor risk in 14 countries. The study, which aims to include approximately 1,000 brain tumor cases aged 10–24 years and two individually matched controls for each case, follows a common protocol and builds upon the methodological experience of the INTERPHONE study. The design and conduct of a study on EMF exposure and brain tumor risk in young people in a large number of countries is complex and poses methodological challenges. This manuscript discusses the design of MOBI-Kids and describes the challenges and approaches chosen to address them, including: (1) the choice of controls operated for suspected appendicitis, to reduce potential selection bias related to low response rates among population controls; (2) investigating a young study population spanning a relatively wide age range; (3) conducting a large, multinational epidemiological study, while adhering to increasingly stricter ethics requirements; (4) investigating a rare and potentially fatal disease; and (5) assessing exposure to EMF from communication technologies. Our experience in thus far developing and implementing the study protocol indicates that MOBI-Kids is feasible and will generate results that will contribute to the understanding of potential brain tumor risks associated with use of mobile phones and other wireless communications technologies among young people.
机译：年轻人使用手机的迅速增加引起了人们对暴露于射频（RF）和极低频（ELF）电磁场（EMF）可能对健康造成的影响的担忧。 MOBI-Kids是一项跨国病例对照研究，研究了14个国家中儿童和青少年通过移动通信技术接触EMF对脑瘤风险的潜在影响。该研究旨在包括大约1,000名年龄在10-24岁之间的脑肿瘤病例，以及针对每种情况的两个单独匹配的对照，该研究遵循共同的协议，并借鉴了INTERPHONE研究的方法学经验。在许多国家/地区，有关年轻人中EMF暴露和脑瘤风险的研究的设计和进行是复杂的，并在方法上提出了挑战。该手稿讨论了MOBI-Kids的设计，并描述了应对这些挑战的方法和途径，包括：（1）选择可疑阑尾炎的对照，以减少与人群对照中低反应率相关的潜在选择偏见； （2）调查年龄范围较广的年轻研究人群； （3）在遵守日益严格的道德规范要求的同时，进行大规模的跨国流行病学研究； （4）调查一种罕见且可能致命的疾病； （5）评估通信技术对EMF的影响。到目前为止，我们在开发和实施研究方案方面的经验表明，MOBI-Kids是可行的，并将产生有助于理解年轻人与使用手机和其他无线通信技术相关的潜在脑肿瘤风险的结果。

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