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首页> 美国卫生研究院文献>American Journal of Epidemiology >Assessing the Influence of Traffic-related Air Pollution on Risk of Term Low Birth Weight on the Basis of Land-Use-based Regression Models and Measures of Air Toxics
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Assessing the Influence of Traffic-related Air Pollution on Risk of Term Low Birth Weight on the Basis of Land-Use-based Regression Models and Measures of Air Toxics

机译：基于土地利用的回归模型和空气毒理措施评估与交通有关的空气污染对足月低出生体重风险的影响

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Few studies have examined associations of birth outcomes with toxic air pollutants (air toxics) in traffic exhaust. This study included 8,181 term low birth weight (LBW) children and 370,922 term normal-weight children born between January 1, 1995, and December 31, 2006, to women residing within 5 miles (8 km) of an air toxics monitoring station in Los Angeles County, California. Additionally, land-use-based regression (LUR)-modeled estimates of levels of nitric oxide, nitrogen dioxide, and nitrogen oxides were used to assess the influence of small-area variations in traffic pollution. The authors examined associations with term LBW (≥37 weeks’ completed gestation and birth weight <2,500 g) using logistic regression adjusted for maternal age, race/ethnicity, education, parity, infant gestational age, and gestational age squared. Odds of term LBW increased 2%–5% (95% confidence intervals ranged from 1.00 to 1.09) per interquartile-range increase in LUR-modeled estimates and monitoring-based air toxics exposure estimates in the entire pregnancy, the third trimester, and the last month of pregnancy. Models stratified by monitoring station (to investigate air toxics associations based solely on temporal variations) resulted in 2%–5% increased odds per interquartile-range increase in third-trimester benzene, toluene, ethyl benzene, and xylene exposures, with some confidence intervals containing the null value. This analysis highlights the importance of both spatial and temporal contributions to air pollution in epidemiologic birth outcome studies.
机译：很少有研究检查出生结局与交通尾气中有毒空气污染物（空气中的有毒物质）的关系。这项研究包括1995年1月1日至2006年12月31日期间出生的8181名足月低体重儿和370922足月体重正常儿，这些妇女居住在洛斯空气毒物监测站5英里（8公里）内加利福尼亚州安吉利斯县。此外，基于土地利用的回归（LUR）建模的一氧化氮，二氧化氮和氮氧化物水平估计值还用于评估小面积变化对交通污染的影响。作者使用逻辑回归对孕产妇年龄，种族/族裔，教育程度，均等性，婴儿胎龄和胎龄平方进行了逻辑回归，检验了与足月出生体重（≥37周的完整妊娠和出生体重<2,500 g）的关联。在整个妊娠，孕中期和中期，LUR模型估算值和基于监测的空气毒物暴露估算值的每四分位数间距增加，足月LBW的几率增加2％–5％（95％置信区间为1.00至1.09）。怀孕的最后一个月。由监测站进行分层的模型（仅根据时间变化来调查空气中的毒物关联）导致三季孕期苯，甲苯，乙苯和二甲苯暴露的每四分位数间距增加几率增加2％–5％包含空值。该分析强调了流行病学出生结局研究中时空变化对空气污染的重要性。

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