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首页> 美国卫生研究院文献>Annals of the American Thoracic Society >Patients with Chronic Obstructive Pulmonary Disease Walk with Altered Step Time and Step Width Variability as Compared with Healthy Control Subjects
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Patients with Chronic Obstructive Pulmonary Disease Walk with Altered Step Time and Step Width Variability as Compared with Healthy Control Subjects

机译：与健康对照组相比慢性阻塞性肺疾病患者行走的步伐时间和步幅变异性改变

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>Rationale: Compared with control subjects, patients with chronic obstructive pulmonary disease (COPD) have an increased incidence of falls and demonstrate balance deficits and alterations in mediolateral trunk acceleration while walking. Measures of gait variability have been implicated as indicators of fall risk, fear of falling, and future falls.>Objectives: To investigate whether alterations in gait variability are found in patients with COPD as compared with healthy control subjects.>Methods: Twenty patients with COPD (16 males; mean age, 63.6 ± 9.7 yr; FEV1/FVC, 0.52 ± 0.12) and 20 control subjects (9 males; mean age, 62.5 ± 8.2 yr) walked for 3 minutes on a treadmill while their gait was recorded. The amount (SD and coefficient of variation) and structure of variability (sample entropy, a measure of regularity) were quantified for step length, time, and width at three walking speeds (self-selected and ±20% of self-selected speed). Generalized linear mixed models were used to compare dependent variables.>Results: Patients with COPD demonstrated increased mean and SD step time across all speed conditions as compared with control subjects. They also walked with a narrower step width that increased with increasing speed, whereas the healthy control subjects walked with a wider step width that decreased as speed increased. Further, patients with COPD demonstrated less variability in step width, with decreased SD, compared with control subjects at all three speed conditions. No differences in regularity of gait patterns were found between groups.>Conclusions: Patients with COPD walk with increased duration of time between steps, and this timing is more variable than that of control subjects. They also walk with a narrower step width in which the variability of the step widths from step to step is decreased. Changes in these parameters have been related to increased risk of falling in aging research. This provides a mechanism that could explain the increased prevalence of falls in patients with COPD.
机译：>原理：与对照组相比，慢性阻塞性肺疾病（COPD）患者跌倒的发生率增加，并且步行时表现出平衡不足和中侧躯干加速度改变。 >目标：目的：调查与健康对照组相比，COPD患者的步态变异性是否有变化。 >方法： 20名COPD患者（16名男性；平均年龄63.6±9.7岁； FEV1 / FVC：0.52±0.12岁）和20名对照受试者（9名男性；平均年龄62.5±8.2岁）步行。在跑步机上跑步3分钟，同时记录他们的步态。在三种步行速度（自选速度和自选速度的±20％）下，对步长，时间和宽度的数量（SD和变异系数）和可变性结构（样本熵，规律性度量）进行量化。 。 >结果：与对照组相比，COPD患者在所有速度条件下的平均时间和SD步长增加。他们还以随着速度增加而增加的较窄步幅行走，而健康对照组的参与者以随着速度增加而减少的较宽步幅行走。此外，与所有三种速度条件下的对照受试者相比，COPD患者的步幅变异性较小，SD降低。在各组之间没有发现步态规律的规律性差异。>结论： COPD患者行走的步长持续时间增加，并且这个时机比对照组的人更易变。它们还以较窄的步幅行走，其中步距之间的步幅变化减小了。这些参数的变化与衰老研究的下降风险增加有关。这提供了一种机制，可以解释COPD患者跌倒患病率的增加。

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