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首页> 美国卫生研究院文献>AIDS Research and Human Retroviruses >Transmitted/Founder HIV-1 Subtype C Viruses Show Distinctive Signature Patterns in Vif Vpr and Vpu That Are Under Subsequent Immune Pressure During Early Infection
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Transmitted/Founder HIV-1 Subtype C Viruses Show Distinctive Signature Patterns in Vif Vpr and Vpu That Are Under Subsequent Immune Pressure During Early Infection

机译：已传播/创始人的HIV-1 C型亚型病毒在VifVpr和Vpu中表现出明显的特征码这些特征码在早期感染期间处于随后的免疫压力之下

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摘要

Viral variants that predominate during early infection may exhibit constrained diversity compared with those found during chronic infection and could contain amino acid signature patterns that may enhance transmission, establish productive infection, and influence early events that modulate the infection course. We compared amino acid distributions in 17 patients recently infected with HIV-1C with patients with chronic infection. We found significantly lower entropy in inferred transmitted/founder (t/f) compared with chronic viruses and identified signature patterns in Vif and Vpr from inferred t/f viruses. We investigated sequence evolution longitudinally up to 500 days postseroconversion and compared the impact of selected substitutions on predicted human leukocyte antigen (HLA) binding affinities of published and predicted cytotoxic T-lymphocyte epitopes. Polymorphisms in Vif and Vpr during early infection occurred more frequently at epitope-HLA anchor residues and significantly decreased predicted epitope-HLA binding. Transmission-associated sequence signatures may have implications for novel strategies to prevent HIV-1 transmission.
机译：与在慢性感染期间发现的病毒变体相比，在早期感染期间占优势的病毒变体可能表现出受限制的多样性，并且可能包含氨基酸特征码型，可以增强传播，建立生产性感染并影响调节感染过程的早期事件。我们比较了17位最近感染HIV-1C的患者和慢性感染患者的氨基酸分布。我们发现与慢性病毒相比，推断的传播/建立者（t / f）的熵显着降低，并且在推断的t / f病毒的Vif和Vpr中确定了特征码模式。我们调查了直至转化后500天的纵向序列进化，并比较了所选替代对已发布和预测的细胞毒性T淋巴细胞表位的预测人类白细胞抗原（HLA）结合亲和力的影响。早期感染期间Vif和Vpr的多态性在表位-HLA锚残基处更常见，并且显着降低了预测的表位-HLA结合。与传播相关的序列签名可能对预防HIV-1传播的新策略有影响。

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