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首页> 美国卫生研究院文献>AIDS Research and Human Retroviruses >Analysis of Immunological Viral Genetic and Environmental Factors That Might Be Associated with Decreased Susceptibility to HIV Infection in Serodiscordant Couples in Florianópolis Southern Brazil
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Analysis of Immunological Viral Genetic and Environmental Factors That Might Be Associated with Decreased Susceptibility to HIV Infection in Serodiscordant Couples in Florianópolis Southern Brazil

机译：在巴西南部弗洛里亚诺波利斯的血清脂溶性夫妇中可能与HIV感染易感性降低相关的免疫病毒遗传和环境因素分析

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Individuals who have been exposed to human immunodeficiency virus (HIV) and have not been infected might possess natural resistance mechanisms. An understanding of the sociodemographic and immunological conditions that influence resistance to HIV is a challenge, and very little is known about the role of intrinsic antiviral factors that restrict HIV infection. The aim of this study was to analyze potential factors responsible for resistance to HIV infection in serodiscordant couples by comparing HIV-exposed seronegative individuals (HESN) to HIV-seropositive individuals treated with antiretroviral therapy (HIV-ART) along with healthy controls (HC). The results revealed one HLA-B*27 and two HLA-B*57 individuals among the HESN; a CCR5Δ32 heterozygous deletion was observed in one serodiscordant couple, while the homozygous genotype for this variant was not observed. There were no differences in the basal mRNA expression of APOBEC3G, CFLAR, TRIM5α, LEDGF/p75, BST-2, or SAMHD1 in CD4+ T lymphocyte- and monocyte-enriched populations among the three groups, and lower HBD-3 concentrations were observed in saliva from HIV-ART compared to HESN and HC. The most prevalent HIV-1 subtype was C or C-containing recombinant forms. Six HIV-ART individuals and one HIV-ART individual were infected with the R5 HIV and X4 HIV strains, respectively. The ability to control infection or delay disease progression is probably defined by a balance between viral and host factors, and further evaluation should be performed in larger cohorts. Our data suggest that susceptibility to HIV infection varies among individuals and strengthens the multifactorial characteristics underlying the resistance mechanisms in HIV.
机译：暴露于人类免疫缺陷病毒（HIV）且未感染的个体可能具有自然抵抗力机制。了解影响艾滋病毒耐药性的社会人口统计学和免疫学状况是一个挑战，而对于限制艾滋病毒感染的内在抗病毒因素的作用了解甚少。这项研究的目的是通过比较暴露于HIV的血清阴性个体（HESN）与接受抗逆转录病毒疗法（HIV-ART）以及健康对照（HC）治疗的HIV血清阳性个体，来分析血清抗体对夫妇对HIV感染产生抵抗力的潜在因素。结果显示，HESN中有1名HLA-B * 27和2名HLA-B * 57。在一对血清抗体中观察到CCR5Δ32杂合缺失，而未观察到该变体的纯合基因型。三组中CD4 T淋巴细胞和单核细胞丰富的人群中APOBEC3G，CFLAR，TRIM5α，LEDGF / p75，BST-2或SAMHD1的基础mRNA表达没有差异，并且与HESN和HC相比，HIV-ART唾液中的HBD-3浓度较低。最流行的HIV-1亚型是C或含C的重组形式。分别有6个HIV-ART个体和1个HIV-ART个体感染了R5 HIV和X4 HIV毒株。控制感染或延缓疾病进展的能力可能是由病毒和宿主因素之间的平衡来定义的，应在较大的人群中进行进一步评估。我们的数据表明，HIV感染的易感性因人而异，并加强了HIV耐药机制的多因素特征。

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