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Full Genome Characterization of a New Simian Immune Deficiency Virus Lineage in a Naturally Infected Cercopithecus ascanius whitesidei in the Democratic Republic of Congo Reveals High Genetic Diversity Among Red-Tailed Monkeys in Central and Eastern Africa

机译:刚果民主共和国受自然感染的Cercopithecus ascanius whitesidei的新猿猴免疫缺陷病毒谱系的全基因组表征揭示了中部和东部非洲红尾猴的高度遗传多样性

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摘要

Our knowledge on simian immune deficiency virus (SIV) diversity and evolution in the different nonhuman primate species is still incomplete. In this study, we report the full genome characterization of a new SIV from a red-tailed monkey (2013DRC-I8), from the Cercopithecus ascanius whitesidei subspecies, in the Democratic Republic of Congo (DRC). The new full-length genome is 9,926 bp long, and the genomic structure is similar to that of other SIVs with the absence of vpx and vpu genes. The new SIVasc-13DRC-I8 strain fell within the Cercopithecus specific SIV lineage. SIVasc-13DRC-I8 and previously reported SIVrtg from the C.a. schmidti subspecies in Uganda did not form a separate species-specific SIV lineage. These observations provide additional evidence for high genetic diversity and the complex evolution of SIVs in the Cercopithecus genus. More studies on a large number of monkeys from a wider geographic area are needed to understand SIV evolution.
机译:我们对猿猴免疫缺陷病毒(SIV)在不同的非人类灵长类动物物种中的多样性和进化的了解仍然不完整。在这项研究中,我们报告了来自刚果民主共和国(DRC)的长尾猴ascanius whitesidei亚种的红尾猴(2013DRC-I8)的新SIV的完整基因组特征。新的全长基因组长9926 bp,基因组结构与其他SIV的相似,但没有vpx和vpu基因。新的SIVasc-13DRC-I8菌株属于Cercopithecus特有的SIV谱系。 SIVasc-13DRC-I8和先前从C.a.报道的SIVrtg。乌干达的schmidti亚种未形成单独的物种特异性SIV谱系。这些观察结果为鹿皮属属中的高遗传多样性和SIV的复杂进化提供了额外的证据。为了了解SIV的进化,需要对来自更广泛地理区域的大量猴子进行更多研究。

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