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首页> 美国卫生研究院文献>The American Journal of Clinical Nutrition >A low-fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized controlled 74-wk clinical trial
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A low-fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized controlled 74-wk clinical trial

机译：低脂纯素饮食和常规糖尿病饮食治疗2型糖尿病：随机对照74周临床试验

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>Background: Low-fat vegetarian and vegan diets are associated with weight loss, increased insulin sensitivity, and improved cardiovascular health.>Objective: We compared the effects of a low-fat vegan diet and conventional diabetes diet recommendations on glycemia, weight, and plasma lipids.>Design: Free-living individuals with type 2 diabetes were randomly assigned to a low-fat vegan diet (n = 49) or a diet following 2003 American Diabetes Association guidelines (conventional, n = 50) for 74 wk. Glycated hemoglobin (Hb A1c) and plasma lipids were assessed at weeks 0, 11, 22, 35, 48, 61, and 74. Weight was measured at weeks 0, 22, and 74.>Results: Weight loss was significant within each diet group but not significantly different between groups (−4.4 kg in the vegan group and −3.0 kg in the conventional diet group, P = 0.25) and related significantly to Hb A1c changes (r = 0.50, P = 0.001). Hb A1c changes from baseline to 74 wk or last available values were −0.34 and −0.14 for vegan and conventional diets, respectively (P = 0.43). Hb A1c changes from baseline to last available value or last value before any medication adjustment were −0.40 and 0.01 for vegan and conventional diets, respectively (P = 0.03). In analyses before alterations in lipid-lowering medications, total cholesterol decreased by 20.4 and 6.8 mg/dL in the vegan and conventional diet groups, respectively (P = 0.01); LDL cholesterol decreased by 13.5 and 3.4 mg/dL in the vegan and conventional groups, respectively (P = 0.03).>Conclusions: Both diets were associated with sustained reductions in weight and plasma lipid concentrations. In an analysis controlling for medication changes, a low-fat vegan diet appeared to improve glycemia and plasma lipids more than did conventional diabetes diet recommendations. Whether the observed differences provide clinical benefit for the macro- or microvascular complications of diabetes remains to be established. This trial was registered at as .
机译：>背景：低脂素食和纯素食与体重减轻，胰岛素敏感性增加和心血管健康相关。>目的：我们比较了低脂素食的效果饮食和常规糖尿病饮食中有关血糖，体重和血脂的建议。>设计： 2型糖尿病的自由生活者被随机分配为低脂素食（n = 49）或饮食遵循2003年美国糖尿病协会指南（常规，n = 50）达74周。在第0、11、22、35、48、61和74周评估了糖化血红蛋白（Hb A1c）和血浆脂质。在0、22和74周测量了体重。>结果：每个饮食组中的损失显着，但各组之间无显着差异（素食组为-4.4 kg，常规饮食组为-3.0 kg，P = 0.25），并且与Hb A1c的变化显着相关（r = 0.50，P = 0.001） ）。素食和常规饮食的Hb A1c从基线到74 wk的变化或最后可用值分别为-0.34和-0.14（P = 0.43）。素食和常规饮食的Hb A1c从基线到最后一个可用值或在任何药物调整之前的最后一个值分别为-0.40和0.01（P = 0.03）。在降脂药物变更之前的分析中，纯素饮食组和常规饮食组的总胆固醇分别降低了20.4和6.8 mg / dL（P = 0.01）；素食组和常规组的LDL胆固醇分别降低13.5和3.4 mg / dL（P = 0.03）。>结论：两种饮食都与体重和血浆脂质浓度的持续降低有关。在控制药物变化的分析中，低脂纯素食饮食似乎比常规糖尿病饮食建议改善的血糖和血浆脂质更多。观察到的差异是否为糖尿病的大血管或微血管并发症提供临床益处尚待确定。该审判的注册地址为。

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