• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>AIDS Research and Human Retroviruses >Short Communication: Molecular Epidemiology of HIV Type 1 Infection in Northern Greece (2009–2010): Evidence of a Transmission Cluster of HIV Type 1 Subtype A1 Drug-Resistant Strains Among Men Who Have Sex with Men
【2h】

Short Communication: Molecular Epidemiology of HIV Type 1 Infection in Northern Greece (2009–2010): Evidence of a Transmission Cluster of HIV Type 1 Subtype A1 Drug-Resistant Strains Among Men Who Have Sex with Men

机译：简短交流：希腊北部HIV 1型感染的分子流行病学研究（2009年至2010年）：与男性发生性行为的HIV 1型亚型A1亚型耐药菌株传播群的证据

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A prospective molecular epidemiology study of HIV-1 infection was conducted in newly diagnosed and antiretroviral-naive patients in Northern Greece between 2009 and 2010 using a predefined enrolling strategy. Phylogenetic trees of the pol sequences obtained in this study with reference sequences indicated that subtypes B and A1 were the most common subtypes present and accounted for 44.9% and 42.9%, respectively, followed by subtype C (3.1%), CRF02_AG (4.1%), CRF04_cpx (2.0%), and subtypes CRF01_01, F1, and G (1.0%). A high rate of clustered transmission of subtype A1-resistant strains to reverse transcriptase (RT) inhibitors was observed among men having sex with men. Indeed, 15 out of 17 study subjects (88.2%) infected with transmitted drug resistance (TDR) strains were implicated in transmission clusters, 10 of whom (66.7%) were men who have sex with men (MSM), and were also infected with subsubtype A1 strains. The main cluster within subtype A1 (I) included eight men reporting having sex with men from Thessaloniki infected with dual-class RT-resistant strains carrying both T215C and Y181C mutations.
机译：使用预定的招募策略，在2009年至2010年之间，对希腊北部新诊断和未接受过抗逆转录病毒治疗的患者进行了HIV-1感染的前瞻性分子流行病学研究。本研究中获得的带有参考序列的pol序列的系统发育树表明，存在的B型和A1型是最常见的亚型，分别占44.9％和42.9％，其次是C型（3.1％），CRF02_AG（4.1％） ，CRF04_cpx（2.0％）和子类型CRF01_01，F1和G（1.0％）。在与男性发生性关系的男性中，观察到A1型亚型耐药菌株向逆转录酶（RT）抑制剂的高聚集传播率。确实，在感染了传播耐药性（TDR）菌株的17名研究对象中，有15名（88.2％）与传播群有关，其中10名（66.7％）是与男性发生性关系（MSM）的男性，并且还感染了亚型A1菌株。 A1（I）亚型中的主要人群包括八名男子，他们与塞萨洛尼基的男子发生过性行为，感染了携带T215C和Y181C突变的双重RT耐药菌株。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号