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The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the field

机译:叶黄素和玉米黄质作为对抗年龄相关性黄斑变性的保护剂的公认作用:分子遗传学有望指导该领域的机制和翻译研究

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摘要

Age-related macular degeneration (AMD) is the primary cause of vision loss in elderly people of western European ancestry. Genetic, dietary, and environmental factors affect tissue concentrations of macular xanthophylls (MXs) within retinal cell types manifesting AMD pathology. In this article we review the history and state of science on the putative role of the MXs (lutein, zeaxanthin, and meso-zeaxanthin) in AMD and report findings on AMD-associated genes encoding enzymes, transporters, ligands, and receptors affecting or affected by MXs. We then use this context to discuss emerging research opportunities that offer promise for meaningful investigation and inference in the field.
机译:与年龄有关的黄斑变性(AMD)是西欧裔老年人视力丧失的主要原因。遗传因素,饮食因素和环境因素会影响表现出AMD病理的视网膜细胞类型内的黄斑叶黄素(MXs)组织浓度。在本文中,我们回顾了MX(叶黄素,玉米黄质和内消旋玉米黄质)在AMD中的假定作用的历史和科学状况,并报告了与AMD相关的基因编码结果,这些基因编码影响或受影响的酶,转运蛋白,配体和受体通过MX。然后,我们使用此上下文来讨论新兴的研究机会,这些机会为该领域的有意义的研究和推断提供了希望。

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