首页> 美国卫生研究院文献>American Journal of Epidemiology >Less subclinical atherosclerosis in Japanese men in Japan than in white men in the United States in the post World-War-II birth cohort
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Less subclinical atherosclerosis in Japanese men in Japan than in white men in the United States in the post World-War-II birth cohort

机译:在第二次世界大战后出生的队列中日本的日本男性患亚临床动脉粥样硬化的人数要少于美国的白人男性

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摘要

Coronary heart disease (CHD) incidence and mortality remain very low in Japan despite major dietary changes and increases in CHD risk factors that should have resulted in substantial increase in CHD rates (Japanese paradox). Primary genetic effects are unlikely, given the substantial increase in CHD in migrant Japanese to the U.S. For men aged 40–49, levels of total cholesterol and blood pressure have been similar in Japan and the U.S. throughout their lifetime. The authors tested the hypothesis that levels of subclinical atherosclerosis, coronary artery calcification and intima-media thickness of the carotid artery (IMT), in men aged 40–49 are similar in Japan and the U.S. The authors conducted a population-based study of 493 randomly-selected men: 250 men in Kusatsu, Shiga, Japan, and 243 white men in Allegheny County, Pennsylvania, U.S. in 2002–2005. The Japanese had a less favorable profile of many risk factors than the whites. Prevalence ratio for the presence of coronary calcium score ≥10 in the Japanese compared to the whites was 0.52 (95% CI, 0.35, 0.76). Mean (SE) IMT was significantly lower in the Japanese (0.616 (0.005) versus 0.672 (0.005) mm, p<0.01). Both associations remained significant after adjusting for risk factors. The findings warrant further investigations.
机译:尽管饮食结构发生了重大变化,而且冠心病危险因素的增加本应导致冠心病发生率的大幅上升,但日本的冠心病(CHD)发病率和死亡率仍然很低(日本自相矛盾)。鉴于日本移民到美国的冠心病大幅增加,主要的遗传效应不太可能。对于40-49岁的男性,日本和美国的一生中总胆固醇和血压水平相似。作者检验了以下假设:日本和美国的40-49岁男性的亚临床动脉粥样硬化,冠状动脉钙化和颈动脉内膜中层厚度相似。作者进行了一项针对493人的基于人群的研究随机选择的男性:2002年至2005年,日本滋贺县草津市的250名男性和美国宾夕法尼亚州阿勒格尼县的243名白人。与白人相比,日本人在许多危险因素方面的印象较差。日本人与白人相比,冠状动脉钙分数≥10的患病率是0.52(95%CI,0.35,0.76)。日本人的平均(SE)IMT明显较低(0.616(0.005)mm,而0.672(0.005)mm,p <0.01)。调整风险因素后,两个关联仍然显着。调查结果值得进一步调查。

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