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首页> 美国卫生研究院文献>Brain Behavior and Evolution >Plasticity of Auditory Medullary-Midbrain Connectivity across Metamorphic Development in the Bullfrog Rana catesbeiana
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Plasticity of Auditory Medullary-Midbrain Connectivity across Metamorphic Development in the Bullfrog Rana catesbeiana

机译：蛙蛙蛙变态发育过程中听觉髓质-中脑连通性的可塑性

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On the basis of patterns of anterograde, retrograde, and bi-directional transport of tracers from both the superior olivary nucleus (SON) and the torus semicircularis (TS), we report anatomical changes in brainstem connectivity across metamorphic development in the bullfrog, Rana catesbeiana. In early and late stages of larval development (Gosner stages 25–37), anterograde or bi-directional tracers injected into the SON produce terminal/fiber label in the contralateral SON and in the ipsilateral TS. Between stages 38–41 (deaf period), only sparse or no terminal/fiber label is visible in these target nuclei. During metamorphic climax (stages 42–46), terminal/fiber label reappears in both the contralateral SON and in the ipsilateral TS, and now also in the contralateral TS. Injections of retrograde tracers into the SON fail to label cell bodies in the ipsilateral TS in deaf period animals, mirroring the previously-reported failure of retrograde transport from the TS to the ipsilateral SON during this developmental time. Bilateral cell body label emerges in the dorsal medullary nucleus and the lateral vestibular nucleus bilaterally as a result of SON transport during the late larval period, while cell body label in the contralateral TS emerges during climax. At all larval stages, injections into the SON produce anterograde and retrograde label in the medial vestibular nucleus bilaterally. These data show anatomical stability in some pathways and plasticity in others during larval development, with the most dramatic changes occurring during the deaf period and metamorphic climax. Animals in metamorphic climax show patterns of connectivity similar to that of froglets and adults, indicating the maturation during climax of central anatomical substrates for hearing in air.
机译：基于示踪剂从上位橄榄核（SON）和半圆环（TS）的示踪剂的顺行，逆行和双向转运的模式，我们报告了牛蛙，蛙蛙的变质发育中脑干连通性的解剖变化。 。在幼虫发育的早期和晚期（Gosner阶段25-37），注入SON的顺行或双向示踪剂会在对侧SON和同侧TS中产生末端/纤维标签。在第38-41阶段（聋期）之间，在这些目标核中只有稀疏的或没有末端/纤维标记。在变态的高潮期间（阶段42-46），对侧SON和同侧TS中以及现在对侧TS中都再次出现末端/纤维标签。向SON注射逆行示踪剂未能标记聋期动物同侧TS的细胞体，这反映了先前报道的在这段发育时间内从TS向同侧SON逆行转运的失败。在幼虫后期后期，SON转运在双侧背侧髓核和前庭外侧核中出现双侧细胞体标记，而在高潮期则在对侧TS中出现双侧细胞体标记。在所有幼虫阶段，SON的注射都会在双侧前庭内侧核中产生顺行和逆行标签。这些数据显示了幼虫发育过程中某些途径的解剖学稳定性和另一些途径的可塑性，其中最大的变化发生在聋期和变态高潮。处于变态高潮的动物显示出类似于小青蛙和成年动物的连通性模式，这表明在中央解剖基质在空气中聆听的高潮过程中成熟。

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