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首页> 美国卫生研究院文献>Cerebral Cortex (New York NY) >The Neural Organization of Semantic Control: TMS Evidence for a Distributed Network in Left Inferior Frontal and Posterior Middle Temporal Gyrus
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The Neural Organization of Semantic Control: TMS Evidence for a Distributed Network in Left Inferior Frontal and Posterior Middle Temporal Gyrus

机译：语义控制的神经组织：左下额额叶和后中颞颞回分布式网络的TMS证据

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摘要

Assigning meaning to words, sounds, and objects requires stored conceptual knowledge plus executive mechanisms that shape semantic retrieval according to the task or context. Despite the essential role of control in semantic cognition, its neural basis remains unclear. Neuroimaging and patient research has emphasized the importance of left inferior frontal gyrus (IFG)—however, impaired semantic control can also follow left temporoparietal lesions, suggesting that this function may be underpinned by a large-scale cortical network. We used repetitive transcranial magnetic stimulation in healthy volunteers to disrupt processing within 2 potential sites in this network—IFG and posterior middle temporal cortex. Stimulation of both sites selectively disrupted executively demanding semantic judgments: semantic decisions based on strong automatic associations were unaffected. Performance was also unchanged in nonsemantic tasks—irrespective of their executive demands—and following stimulation of a control site. These results reveal that an extended network of prefrontal and posterior temporal regions underpins semantic control.
机译：为单词，声音和对象分配含义需要存储的概念知识以及根据任务或上下文塑造语义检索的执行机制。尽管控制在语义认知中起着至关重要的作用，但其神经基础仍不清楚。神经影像学和患者研究已经强调了左下额回（IFG）的重要性-但是，语义控制受损也可以跟随左颞顶病变，这表明该功能可能由大规模皮质网络支撑。我们在健康志愿者中使用重复经颅磁刺激来破坏该网络中两个潜在部位（IFG和颞中后叶）的加工。对两个站点的刺激有选择地打断了执行要求高的语义判断：基于强大自动关联的语义决策不受影响。在非语义任务中，无论执行要求如何，以及在刺激控制点之后，性能也没有变化。这些结果表明，前后额颞区的扩展网络支撑了语义控制。

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