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首页> 美国卫生研究院文献>Blood >Plenary Paper: Sexual function changes during the 5 years after high-dose treatment and hematopoietic cell transplantation for malignancy with case-matched controls at 5 years
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Plenary Paper: Sexual function changes during the 5 years after high-dose treatment and hematopoietic cell transplantation for malignancy with case-matched controls at 5 years

机译：全体会议：大剂量治疗和造血细胞移植治疗恶性肿瘤后的5年内性功能发生变化病例对照在5年后发生变化

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This prospective study evaluated sexual function through 5 years after myeloablative allogeneic hematopoietic cell transplantation (HCT) for cancer to determine sexual function recovery and residual problems. Adults completed measures before HCT (N = 161), with survivors followed at 6 months and at 1, 2, 3, and 5 years. At 5 years case-matched controls also completed assessments. Analyses indicated that men and women differed in rates of being sexually active across time (P < .001) and in overall sexual function (P < .001). Both sexes declined in sexual activity rates and sexual function from before HCT to 6 months afterward (P ≤ .05). Activity rates recovered for men by 1 year (74%) and for women by 2 years (55%). Men improved from their 6-month nadir in sexual function by 2 years (P = .02), whereas women did not improve by 5 years (P = .17). Both male and female survivors were below controls in rates of sexual activity and sexual function at 5 years. Most women reported sexual problems (80% of survivors vs 61% of controls, P = .11); in contrast for men 46% of survivors versus 21% of controls (P = .05) reported problems. Thus, despite some recovery, sexual dysfunction remained a major problem for men and women after HCT. Aggressive efforts are needed to treat these deficits.
机译：这项前瞻性研究评估了清髓性同种异体造血细胞移植（HCT）进行癌症治疗后5年的性功能，以确定性功能恢复和残留问题。成人在HCT之前完成了测量（N = 161），幸存者在6个月，1、2、3和5岁时随访。在5年时，与病例匹配的对照也完成了评估。分析表明，男性和女性的跨性别性活跃率（P <.001）和总体性功能（P <.001）有所不同。从HCT之前到术后6个月，男女的性活动率和性功能均下降（P≤.05）。男性的活动率恢复了1年（74％），女性的活动率恢复了2年（55％）。男性的性功能从六个月的最低点提高了2年（P = .02），而女性的性功能没有提高5年（P = .17）。男性和女性幸存者在5年时的性活动和性功能均低于控制水平。大多数妇女报告有性问题（80％的幸存者与61％的对照组相比，P = .11）；相比之下，男性有46％的幸存者与21％的对照组（P = 0.05）报告有问题。因此，尽管有一定程度的恢复，但性功能障碍仍然是HCT后男女的主要问题。需要采取积极的措施来解决这些缺陷。

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