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首页> 美国卫生研究院文献>Journal of Neuroinflammation >Arginine vasopressin altered the expression of monocarboxylate transporters in cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats
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Arginine vasopressin altered the expression of monocarboxylate transporters in cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats

机译：精氨酸加压素改变了中风自发性高血压大鼠和同基因SHRpch1_18大鼠星形胶质细胞中单羧酸盐转运蛋白的表达

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BackgroundAstrocytes support a range of brain functions as well as neuronal survival, but their detailed relationship with stroke-related edema is not well understood. We previously demonstrated that the release of lactate from astrocytes isolated from stroke-prone spontaneously hypertensive rats (SHRSP/Izm) was attenuated under stroke conditions. The supply of lactate to neurons is regulated by astrocytic monocarboxylate transporters (MCTs). The purpose of this study was to examine the contributions of arginine vasopressin (AVP) and/or hypoxia and reoxygenation (H/R) to the regulation of MCTs and neurotrophic factor in astrocytes obtained from SHRSP/Izm and congenic SHRpch1_18 rats.
机译：背景星形胶质细胞支持一系列的脑功能以及神经元存活，但它们与中风相关性水肿的详细关系尚不清楚。我们先前证明，从中风易发性高血压大鼠（SHRSP / Izm）分离的星形胶质细胞释放的乳酸在中风条件下会减弱。乳酸向神经元的供应受星形细胞单羧酸盐转运蛋白（MCT）的调节。这项研究的目的是检查精氨酸加压素（AVP）和/或缺氧和复氧（H / R）对SHRSP / Izm和同系SHRpch1_18大鼠星形胶质细胞中MCT和神经营养因子的调节作用。

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