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首页> 美国卫生研究院文献>The FASEB Journal >Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits
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Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits

机译：阿片类药物基因的区域内和区域间调节：脊髓回路中对称性的破坏

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Regulation of the formation and rewiring of neural circuits by neuropeptides may require coordinated production of these signaling molecules and their receptors that may be established at the transcriptional level. Here, we address this hypothesis by comparing absolute expression levels of opioid peptides with their receptors, the largest neuropeptide family, and by characterizing coexpression (transcriptionally coordinated) patterns of these genes. We demonstrated that expression patterns of opioid genes highly correlate within and across functionally and anatomically different areas. Opioid peptide genes, compared with their receptor genes, are transcribed at much greater absolute levels, which suggests formation of a neuropeptide cloud that covers the receptor-expressed circuits. Surprisingly, we found that both expression levels and the proportion of opioid receptors are strongly lateralized in the spinal cord, interregional coexpression patterns are side specific, and intraregional coexpression profiles are affected differently by left- and right-side unilateral body injury. We propose that opioid genes are regulated as interconnected components of the same molecular system distributed between distinct anatomic regions. The striking feature of this system is its asymmetric coexpression patterns, which suggest side-specific regulation of selective neural circuits by opioid neurohormones.—Kononenko, O., Galatenko, V., Andersson, M., Bazov, I., Watanabe, H., Zhou, X. W., Iatsyshyna, A., Mityakina, I., Yakovleva, T., Sarkisyan, D., Ponomarev, I., Krishtal, O., Marklund, N., Tonevitsky, A., Adkins, D. L., Bakalkin, G. Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits.
机译：通过神经肽调节神经回路的形成和重新布线可能需要协调产生这些信号分子及其在转录水平上建立的受体。在这里，我们通过比较阿片类肽与它们的受体（最大的神经肽家族）的绝对表达水平，以及表征这些基因的共表达（转录协调）模式来解决这个假设。我们证明了阿片样物质基因的表达模式在功能和解剖上不同的区域内和之间高度相关。与它们的受体基因相比，阿片肽基因的绝对水平要高得多，这表明形成了覆盖受体表达回路的神经肽云。出人意料的是，我们发现表达水平和阿片样物质受体的比例在脊髓中都强烈偏侧化，区域间共表达模式是侧特异性的，区域内共表达模式受左侧和右侧单侧身体损伤的影响不同。我们建议，阿片样物质基因被调节为分布在不同解剖区域之间的同一分子系统的相互连接的组成部分。该系统的显着特征是其不对称的共表达模式，这表明阿片类神经激素对选择性神经回路的侧特异性调节。—Kononenko，O.，Galatenko，V.，Andersson，M.，Bazov，I.，Watanabe，H 。，Zhou，XW，Iatsyshyna，A.，Mityakina，I.，Yakovleva，T.，Sarkisyan，D.，Ponomarev，I.，Krishtal，O.，Marklund，N.，Tonevitsky，A.，Adkins，DL， Bakalkin，G.阿片样物质基因的区域内和区域间调节：脊髓回路中对称性的破坏。

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