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首页> 美国卫生研究院文献>Experimental and Therapeutic Medicine >Peritoneal dialysis treatment for severe lupus nephritis patients complicated with essential organ dysfunction
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Peritoneal dialysis treatment for severe lupus nephritis patients complicated with essential organ dysfunction

机译：腹膜透析治疗重度狼疮肾炎并发重要器官功能不全的患者

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The aim of the present study was to evaluate the clinical efficacy of peritoneal dialysis (PD) in patients with severe lupus nephritis (LN) complicated with organ dysfunction. In total, 13 severe LN patients complicated with multiple-organ dysfunction, who underwent PD treatment between November 2003 and September 2010, were enrolled in the study. Six patients received methylprednisolone pulse therapy due to lupus activity and progressive renal failure. These patients were complicated with severe edema, cardiac insufficiency and severe hypoalbuminemia. PD was applied to the patients, followed by the administration of immunosuppressants. Patients were followed-up to review the parameters of renal function, the immunological indexes and the systemic lupus erythematosus disease activity index. The results indicated that the general state of health was markedly improved following PD treatment, with edema abatement and improvement of heart function and physical strength. Serum creatinine levels significantly decreased from 6.3±1.6 to 2.6±1.0 mg/dl. A total of 10 cases ceased PD treatment during the follow-up, while three cases continued PD to the end of the follow-up period. The levels of albumin and hemoglobin exhibited a marked increase from 29.7±5.7 to 35.2±5.5 g/l and 8.7±1.8 to 9.8±1.8 g/l, respectively. There was one case of peritonitis, one case of peritoneal leakage and two cases of pneumonia. Therefore, PD may be a successful treatment method for severe LN patients complicated with essential organ dysfunction. PD not only improved the symptoms of edema and heart failure, but also played an important role in preserving residual renal function and improving the nutritional state of the patients. Thus, PD can be considered as a treatment option for patients with severe LN associated with acute kidney injury, however, selecting a suitable immunosuppressant during PD treatment is essential.
机译：本研究的目的是评估腹膜透析（PD）在重度狼疮性肾炎（LN）并发器官功能障碍患者中的​​临床疗效。该研究共纳入了2003年11月至2010年9月间接受PD治疗的13例重度LN并发多器官功能障碍的重症LN患者。由于狼疮活动和进行性肾衰竭，六名患者接受了甲泼尼龙治疗。这些患者并发严重水肿，心脏功能不全和严重低白蛋白血症。将PD应用于患者，然后给予免疫抑制剂。随访患者的肾脏功能，免疫学指标和系统性红斑狼疮疾病活动性指标。结果表明，PD治疗后总体健康状况得到明显改善，水肿减轻，心脏功能和体力得到改善。血清肌酐水平从6.3±1.6 mg / dl显着降低至2.6±1.0 mg / dl。共有10例在随访期间停止PD治疗，而3例继续PD直至随访期结束。白蛋白和血红蛋白的水平分别从29.7±5.7 g / l和8.7±1.8至9.8±1.8 g / l显着增加。腹膜炎1例，腹膜漏1例，肺炎2例。因此，PD可能是重症LN患者并发实质性器官功能障碍的成功治疗方法。 PD不仅改善了水肿和心力衰竭的症状，而且在保留残余肾功能和改善患者的营养状况方面也起着重要作用。因此，对于患有严重LN并伴有急性肾损伤的严重LN患者，PD可被视为治疗选择，但是，在PD治疗期间选择合适的免疫抑制剂至关重要。

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