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Application value of hypersensitive C-reactive protein lactic acid and myoglobin in the combined detection of myocarditis

机译：超敏C反应蛋白乳酸和肌红蛋白在心肌炎联合检测中的应用价值

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Application value of hypersensitive C-reactive protein (hs-CRP), blood lactic acid (LAC) and myoglobin (Mb) in the combined detection of myocarditis was explored. A total of 107 patients with suspected myocarditis treated in The Second Nanning People's Hospital from January 2015 to December 2017 were retrospectively analyzed, of whom 81 patients diagnosed with myocarditis were enrolled into the research group, and 26 non-myocarditis individuals were enrolled into the control group. Fasting venous blood was drawn from all patients to detect the hs-CRP, LAC and Mb, and their levels were compared and analyzed between the two groups. Moreover, the coincidence rate, sensitivity and specificity of single detection and combined detection by hs-CRP, LAC and Mb in the diagnosis of myocarditis were compared and analyzed. There were no significant differences in the sex, age, smoking status, alcohol consumption, chest distress, palpitation, angina and dyspnea between the two groups (P>0.05), proving that patients in both groups were comparable. The levels of hs-CRP, LAC and Mb in the research group were significantly higher than those in the control group, displaying statistically significant differences (P<0.05). According to the receiver operating characteristic (ROC) curve, the area under the curve (AUC), coincidence rate, sensitivity and specificity in the diagnosis of myocarditis, respectively, were 0.610 (95% CI: 0.495–0.725), 58.88, 51.85 and 80.77% for hs-CRP, 0.657 (95% CI: 0.551–0.763), 58.88, 54.32 and 73.08% for LAC, 0.747 (95% CI: 0.651–0.843), 69.16, 64.20 and 84.62% for Mb, and 0.773 (95% CI: 0.680–0.867), 76.64, 79.01 and 69.23% for combined detection. Hs-CRP, LAC and Mb are highly expressed in the serum of patients with myocarditis, and their combined detection has guiding significance for the prevention and treatment of myocarditis.
机译：探讨了超敏C反应蛋白（hs-CRP），血乳酸（LAC）和肌红蛋白（Mb）在心肌炎联合检测中的应用价值。回顾性分析2015年1月至2017年12月在南宁市第二人民医院治疗的107例疑似心肌炎患者，其中81例确诊为心肌炎的患者纳入研究组，并纳入26例非心肌炎患者作为对照组。组。从所有患者中抽取空腹静脉血以检测hs-CRP，LAC和Mb，并在两组之间进行比较和分析。此外，比较并分析了hs-CRP，LAC和Mb单次检测和联合检测在心肌炎诊断中的符合率，敏感性和特异性。两组在性别，年龄，吸烟状况，饮酒，胸痛，心pa，心绞痛和呼吸困难方面无显着差异（P> 0.05），证明两组患者具有可比性。研究组hs-CRP，LAC和Mb水平明显高于对照组，差异有统计学意义（P <0.05）。根据接受者工作特征（ROC）曲线，曲线下面积（AUC），符合率，敏感性和特异性在诊断心肌炎时分别为0.610（95％CI：0.495-0.725），58.88、51.85和hs-CRP为80.77％，LAC为0.657（95％CI：0.551–0.763），LAC为58.88、54.32和73.08％，Mb为0.747（95％CI：0.651–0.843），Mb为69.16、64.20和84.62％，以及0.773（ 95％CI：0.680–0.867），76.64、79.01和69.23％用于组合检测。 Hs-CRP，LAC和Mb在心肌炎患者血清中高表达，联合检测对预防和治疗心肌炎具有指导意义。

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