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Efficacy of intravenous lidocaine in improving post-operative nausea vomiting and early recovery after laparoscopic gynaecological surgery

机译：腹腔镜妇科手术后静脉注射利多卡因改善恶心呕吐和早期恢复的功效

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Post-operative nausea and vomiting (PONV) is a major peri-operative complication. It has numerous adverse consequences that seriously affect the post-operative recovery of patients. The aim of the present study was to investigate the efficacy of intravenous lidocaine in improving PONV and recovery after laparoscopic gynaecological surgery. A total of 40 patients were randomly assigned to 2 groups: Group L (lidocaine group) and Group C (control group). The patients in Group L received intravenous lidocaine throughout the operation, while patients in Group C were given a saline infusion. Vital signs, recovery time, extubation time, dosage of remifentanil, first flatus time and defecation time of each patient were recorded. The incidence of PONV after surgery was also recorded. The recovery of the patients was evaluated by using the quality of recovery score (QoR-40). The total dose of remifentanil was significantly lower in Group L (P<0.05). However, the recovery time and extubation time were shorter in Group C (P<0.05). The first flatus time and defecation time were longer in Group C (P<0.05). The mean arterial pressure and heart rate in Group L were lower and more stable (P<0.05). At 6 h after surgery, the incidence of PONV was significantly lower in Group L vs. that in Group C (P<0.05). The QoR-40 score in Group C was significantly lower at 1 and 3 days after the operation compared with that in Group C (P<0.05). In conclusion, intravenous lidocaine administered to patients undergoing laparoscopic gynaecological surgery may reduce PONV and supports their early recovery [trial registration number in Chinese Clinical Trial Registry: ChiCTR-IOR-17010782 (March 5, 2017)].
机译：术后恶心和呕吐（PONV）是围手术期的主要并发症。它具有许多不利影响，严重影响患者的术后康复。本研究的目的是研究腹腔镜妇科手术后静脉注射利多卡因改善PONV和恢复的疗效。总共40例患者被随机分为2组：L组（利多卡因组）和C组（对照组）。 L组患者在整个手术过程中接受了静脉注射利多卡因，而C组患者则接受了盐水输注。记录每位患者的生命体征，恢复时间，拔管时间，瑞芬太尼剂量，首次肠胃气胀时间和排便时间。还记录了术后PONV的发生率。使用恢复质量评分（QoR-40）评估患者的恢复情况。 L组雷米芬太尼的总剂量显着降低（P <0.05）。然而，C组的恢复时间和拔管时间较短（P <0.05）。 C组首次肠胃胀气时间和排便时间较长（P <0.05）。 L组平均动脉压和心率较低，较稳定（P <0.05）。术后6 h，L组的PONV发生率明显低于C组（P <0.05）。术后1天和3天，C组的QoR-40得分明显低于C组（P <0.05）。综上所述，腹腔镜妇科手术患者静脉给予利多卡因可能会降低PONV并支持其早期康复[中国临床试验注册中心的注册号：ChiCTR-IOR-17010782（2017年3月5日）]。

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