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Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate

机译：前列地尔联合贝贝磺酸钙联合治疗糖尿病肾病

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This study investigated the effects of alprostadil combined with calcium dobesilate on the treatment of diabetic nephropathy. We recruited 80 patients with diabetic nephropathy, who were randomly divided into experimental (n=40) and control (n=40) groups. Patients received high-quality low-protein diabetic diet intervention and subcutaneous injection of insulin to adjust blood glucose, combined with antihypertensive, antiplatelet drugs, and other comprehensive treatments. The control group received alprostadil and the experimental group received alprostadil combined with calcium dobesilate. Both groups were treated for 12 weeks as one treatment cycle. The time to remission of clinical symptoms such as mental fatigue and weakness, limb edema, soreness and swelling of waist and knee, cold limbs and limb numbness and pain was significantly shorter in the experimental group than that in the control group (p<0.05). After intervention, the blood levels of small molecular weight proteins, such as β2-microglobulin (β2-MG), cystatin C (CysC), and retinol binding protein (RBP), were significantly lower in the experimental group than those in the control group (p<0.05). The levels of the inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP) were significantly lower in the experimental group than those in the control group (p<0.05). The levels of 25-hydroxyvitamin D and parathyroid hormone were significantly higher in the experimental group than those in the control group (p<0.05). The level of angiotensin II was lower in the experimental group than that in the control group (p<0.05) and the level of fasting serum insulin was significantly higher in the experimental group than that in the control group (p<0.05). The homeostasis model assessment of insulin resistance (HOMA-IR) index was lower in the experimental group than that in the control group (p<0.05). The levels of renal function indexes, blood urea nitrogen, creatinine and uric acid, in experimental group were lower than those in control group (p<0.05). The levels of brain derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) were significantly higher in both groups after the intervention than those before the intervention (p<0.05). The levels of BDNF and IGF-1 were higher in the experimental group than that in control group after intervention (p<0.05). The application of alprostadil combined with calcium dobesilate in patients with diabetic nephropathy can effectively relieve clinical symptoms, improve renal functions, reduce blood levels small proteins, alleviate the inflammatory response, and regulate the levels of BDNF and IGF-1, thus improving the clinical treatment effect.
机译：本研究调查了前列地尔联合贝贝磺酸钙治疗糖尿病性肾病的效果。我们招募了80名糖尿病肾病患者，将其随机分为实验组（n = 40）和对照组（n = 40）。患者接受高质量的低蛋白糖尿病饮食干预和皮下注射胰岛素来调节血糖，并结合降压药，抗血小板药和其他综合疗法。对照组接受阿前列地尔，实验组接受阿前列地尔联合贝贝硅酸钙。两组均作为一个治疗周期治疗12周。实验组的精神症状，精神疲倦和无力，四肢浮肿，腰膝酸痛肿胀，四肢发冷，四肢麻木和疼痛等临床症状的缓解时间明显少于对照组（p <0.05） 。干预后，实验组的小分子蛋白质（例如，β2-微球蛋白（β2-MG），半胱氨酸蛋白酶抑制剂C（CysC）和视黄醇结合蛋白（RBP））的血药浓度明显低于对照组。 （p ＜0.05）。实验组炎性细胞因子肿瘤坏死因子-α（TNF-α），白介素-6（IL-6）和C反应蛋白（CRP）的水平显着低于对照组（p < 0.05）。实验组中25-羟基维生素D和甲状旁腺激素的水平明显高于对照组（p <0.05）。实验组的血管紧张素Ⅱ水平低于对照组（p <0.05），空腹血清胰岛素水平明显高于对照组（p <0.05）。实验组胰岛素抵抗稳态模型评估（HOMA-IR）指数低于对照组（p <0.05）。实验组肾脏功能指标，血尿素氮，肌酐和尿酸水平低于对照组（p <0.05）。干预后两组脑源性神经营养因子（BDNF）和胰岛素样生长因子-1（IGF-1）的水平均显着高于干预前（p <0.05）。干预后，实验组BDNF和IGF-1水平高于对照组（p <0.05）。前列地尔联合贝贝磺酸钙在糖尿病肾病患者中的应用可有效缓解临床症状，改善肾脏功能，降低血液中的小蛋白含量，减轻炎症反应，调节BDNF和IGF-1的水平，从而改善临床治疗影响。

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