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Evaluation of the diagnostic performance of panfungal polymerase chain reaction assay in invasive fungal diseases

机译：潘氏真菌聚合酶链反应法在侵袭性真菌病中的诊断性能评价

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Timely diagnosis of invasive fungal diseases (IFDs) is important, as delays in treatment initiation are associated with increased mortality rates. However, early diagnosis of IFDs in immunocompromised patients remains difficult. The conventional diagnostic methods currently used for IFDs are not sufficiently effective. Molecular tests, such as polymerase chain reaction (PCR)-based assays, have great potential to improve the early diagnosis of IFDs due to their sensitivity and specificity. In the present study, the diagnostic performance of panfungal PCR assays in IFD patients who received bone marrow transplantation was evaluated. The results suggested that panfungal PCR assay offered a quick and convenient guide for clinical decision-making by identifying higher numbers of fungal species in comparison with the conventional blood culture method. Furthermore, panfungal PCR assay exhibited a sensitivity of 93% and a specificity of 71% in the diagnosis of IFD patients based on the EORTC/MSG criteria. Thus, the present study concluded that the reported PCR-based method was effective and sensitive in early IFD diagnosis and should be integrated into clinical decision-making for the treatment of IFDs in the future.
机译：及时诊断侵袭性真菌病（IFD）非常重要，因为治疗开始延迟与死亡率增加相关。然而，免疫受损患者中IFD的早期诊断仍然困难。当前用于IFD的常规诊断方法不够有效。分子检测，例如基于聚合酶链反应（PCR）的检测，由于其敏感性和特异性，具有改善IFD早期诊断的巨大潜力。在本研究中，评估了接受真菌移植的IFD患者中Panfungal PCR检测的诊断性能。结果表明，与常规血液培养方法相比，panfungal PCR测定法可通过鉴定更多数量的真菌来为临床决策提供快速便捷的指导。此外，基于EORTC / MSG标准，panfungal PCR检测对IFD患者的诊断具有93％的敏感性和71％的特异性。因此，本研究得出的结论是，所报道的基于PCR的方法在IFD早期诊断中是有效且敏感的，将来应纳入临床决策以治疗IFD。

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