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首页> 美国卫生研究院文献>Experimental and Therapeutic Medicine >Effects of salbutamol aerosol combined with magnesium sulfate on T-lymphocyte subgroup and Th1/Th2 cytokines of pediatric asthma
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Effects of salbutamol aerosol combined with magnesium sulfate on T-lymphocyte subgroup and Th1/Th2 cytokines of pediatric asthma

机译：沙丁胺醇气雾剂联合硫酸镁对小儿哮喘T淋巴细胞亚群和Th1 / Th2细胞因子的影响

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摘要

The aim of the study was to analyze the effects of the intravenous infusion of salbutamol aerosol combined with magnesium sulfate in the treatment of pediatric asthma and the subsequent effects on the levels of T-lymphocyte subgroups and Th1/Th2 cytokines. A total of 86 patients with pediatric asthma, first diagnosed and treated at the Xuzhou Children's Hospital, were continuously selected and randomly divided into an observation group of 44 cases and control group of 42 cases. The patients in the control group were treated with budesonide atomization inhalation, while the children in the observation group were treated with intravenous infusion of salbutamol aerosol combined with magnesium sulfate. The therapeutic effects in the groups were compared. After treatment, the levels of serum CD3+ and CD8+ decreased when compared to before treatment; the levels of CD4+ and CD4+/CD8+ also increased, but the observation group had more significant improvement. Differences were statistically significant (P<0.05). After treatment, the levels of serum interleukin-2 (IL-2) and interferon-γ (IFN-γ) increased when compared to before, while levels of IL-4 and IL-6 decreased, and the observation group had more significant improvement. The differences were statistically significant (P<0.05). After treatment, the levels of VT, t-PTEF/t-E, MTIF/MTEF and TEF75/PTEF increased when compared to before; the observation group had more significant improvement. The differences were statistically significant (P<0.05). The effective rate and degree of treatment for the observation group were significantly higher than those of the control group and differences were statistically significant (P<0.05). The intravenous infusion of salbutamol aerosol combined with magnesium sulfate in the treatment of pediatric asthma can significantly improve therapeutic effects and lung functions, improve immune functions and relieve inflammatory reactions. Therefore, it indicates better clinical application and promotion value.
机译：该研究的目的是分析静脉输注沙丁胺醇气雾剂与硫酸镁联合治疗小儿哮喘的效果，以及其后对T淋巴细胞亚群和Th1 / Th2细胞因子水平的影响。连续选择徐州儿童医院确诊并治疗的86例小儿哮喘患者，随机分为观察组44例和对照组42例。对照组患者接受布地奈德雾化吸入治疗，观察组儿童接受沙丁胺醇气雾剂联合硫酸镁静脉输注治疗。比较各组的治疗效果。治疗后，血清CD3 + 和CD8 + 水平较治疗前下降。 CD4 + 和CD4 + / CD8 + 的水平也有所增加，但观察组的改善更为显着。差异具有统计学意义（P <0.05）。治疗后，血清白细胞介素2（IL-2）和干扰素-γ（IFN-γ）水平较治疗前增加，而IL-4和IL-6水平下降，观察组改善更为明显。 。差异具有统计学意义（P <0.05）。治疗后，VT，t-PTEF / t-E，MTIF / MTEF和TEF75 / PTEF的水平较之前增加；观察组有较明显的改善。差异具有统计学意义（P <0.05）。观察组的有效率和治疗程度明显高于对照组，差异有统计学意义（P <0.05）。沙丁胺醇气雾剂与硫酸镁的静脉输液治疗小儿哮喘可以显着改善治疗效果和肺功能，改善免疫功能并缓解炎症反应。因此，具有较好的临床应用和推广价值。

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