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首页> 美国卫生研究院文献>International Journal of Epidemiology >Work-family life courses and markers of stress and inflammation in mid-life: evidence from the National Child Development Study
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Work-family life courses and markers of stress and inflammation in mid-life: evidence from the National Child Development Study

机译：工作家庭生活过程以及中年压力和炎症的标志：国家儿童发展研究的证据

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>Background: This study investigated associations between work-family life courses and biomarkers of inflammation and stress in mid-life among British men and women. Gender differences in these associations were also explored. >Methods: A novel statistical method—multi-channel sequence analysis—defined work-family life courses between the ages of 16 and 42 years, combining annual information on work, partnership and parenthood. Associations between work-family life courses and inflammation [C-reactive protein (CRP), fibrinogen and von Willebrand factor] and cortisol at age 44/45 years were tested using multivariate linear regression using multiply-imputed data on almost 6500 participants from the National Child Development Study 1958 British birth cohort. >Results: Compared with those who combined strong ties to paid work with later transitions to stable family lives (‘Work, later family’ group), ‘Teen parents’ had higher CRP [40.6% higher, 95% confidence interval (CI): 5.6, 87.0] and fibrinogen (7.8% higher, 95% CI: 2.3, 13.5) levels, and homemakers (‘No paid work, early family’) had raised fibrinogen levels (4.7% higher, 95% CI: 0.7, 9.0), independent of childhood health and socioeconomic position, adult socioeconomic position, health behaviours and body mass index (BMI). Those who combined later transitions to stable family ties with a career break for childrearing had higher post-waking cortisol than the ‘Work, later family’ group; however, no associations were seen for other work-family types, therefore suggesting a null finding with cortisol. No statistically significant gender interactions in associations between work-family types and inflammatory or cortisol outcomes were found. >Conclusions: Work-family life courses characterised by early parenthood or weak work ties were associated with a raised risk profile in relation to chronic inflammation.
机译：>背景：这项研究调查了英国男女在工作家庭生活过程与中年炎症和压力生物标志物之间的关联。还探讨了这些关联中的性别差异。 >方法：一种新颖的统计方法-多渠道序列分析-结合了有关工作，伙伴关系和父母身份的年度信息，定义了16至42岁之间的工作家庭生活课程。使用多元线性回归，采用多元线性回归方法，对来自全国范围内近6500名参与者的数据进行了多元线性回归，检验了工作家庭生活历程与炎症[C反应蛋白（CRP），纤维蛋白原和von Willebrand因子]和皮质醇之间的关联。儿童发展研究1958年英国出生队列。 >结果：与那些将牢固的工作关系与有偿工作结合起来，以后再过渡到稳定的家庭生活的人（“工作，以后的家庭”组）相比，“青少年父母”的CRP更高[分别高40.6％，95％置信区间（CI）：5.6、87.0]和纤维蛋白原水平（高7.8％，95％CI：2.3、13.5）和家庭主妇（“无薪工作，早期家庭”）提高了纤维蛋白原水平（高4.7％，95％） CI：0.7、9.0），独立于儿童健康状况和社会经济地位，成人社会经济地位，健康行为和体重指数（BMI）。那些后来为了稳定家庭关系而过渡到稳定的家庭关系并因抚养孩子而中断职业的人，醒后的皮质醇水平要比“后来的家庭”组高。然而，没有发现其他工作家庭类型的关联，因此提示皮质醇无效。在工作家庭类型与炎症或皮质醇结果之间的关联中，没有发现统计学上显着的性别相互作用。 >结论：以早育儿或工作关系薄为特点的工作家庭生活课程与慢性炎症相关的风险升高。

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