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首页> 美国卫生研究院文献>Thorax >Changes in methacholine induced bronchoconstriction with the long acting beta 2 agonist salmeterol in mild to moderate asthmatic patients.
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Changes in methacholine induced bronchoconstriction with the long acting beta 2 agonist salmeterol in mild to moderate asthmatic patients.

机译：长效β2激动剂沙美特罗在轻度至中度哮喘患者中乙酰甲胆碱引起的支气管收缩变化。

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BACKGROUND--Beta-2 agonists protect against non-specific bronchoconstricting agents such as methacholine, but it has been suggested that the protection afforded by long acting beta 2 agonists wanes rapidly with regular treatment. METHODS--The changes in airway responsiveness were investigated during and after eight weeks of regular treatment with salmeterol 50 micrograms twice daily in 26 adult asthmatic patients, 19 of whom were receiving maintenance inhaled corticosteroids. The study was of a randomised, placebo controlled, double blind design. Airway responsiveness to methacholine was measured as PD20 by a standardised dosimeter technique 12 hours after the first dose, at four weeks and eight weeks during treatment (12 hours after the last dose of test medication), and at 60 hours, one week and two weeks after stopping treatment. RESULTS--There were no significant differences between the baseline characteristics of the two groups. A significant improvement in PD20 was seen at all points during treatment with salmeterol compared with the placebo group, with no significant fall off with time. PD20 measurements returned to baseline values after cessation of treatment with no significant difference from the placebo group. CONCLUSIONS--Salmeterol gave significant protection against methacholine induced bronchoconstriction 12 hours after administration. This protection was of small magnitude, but there was no significant attenuation with eight weeks of regular use and no rebound increase in airway responsiveness on stopping treatment in a group of moderate asthmatic patients, the majority of whom were receiving inhaled corticosteroids.
机译：背景技术-β2激动剂可预防非特异性支气管收缩剂（如甲酰胆碱）的侵害，但已有研究表明，长效β2激动剂提供的保护作用在常规治疗下会迅速消失。方法-在26名成年哮喘患者中，每天两次用沙美特罗50微克常规治疗期间和之后8周，对气道反应性的变化进行了调查，其中19名正在接受维持性吸入糖皮质激素治疗。该研究为随机，安慰剂对照，双盲设计。首次给药后12小时，治疗期间4周和8周（末次试验药物给药12小时后）以及60小时，1周和2周时，通过标准剂量计技术将气道对乙酰甲胆碱的反应性测量为PD20停止治疗后。结果-两组的基线特征之间无显着差异。与安慰剂组相比，在用沙美特罗治疗期间的所有时间点，PD20均得到了显着改善，并且没有随时间推移而出现明显下降。停止治疗后，PD20测量值恢复至基线值，与安慰剂组无显着差异。结论-沙美特罗在给药后12小时对氨甲胆碱引起的支气管收缩具有明显的保护作用。这种保护作用程度不大，但在一组中度哮喘患者中，常规使用八周后，停止治疗后气道反应性没有明显减弱，并且呼吸道反应性没有反弹增加，其中大多数患者正在接受吸入糖皮质激素治疗。

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