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ImageMiner: a software system for comparative analysis of tissue microarrays using content-based image retrieval high-performance computing and grid technology

机译:ImageMiner:使用基于内容的图像检索高性能计算和网格技术对组织微阵列进行比较分析的软件系统

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摘要

Objective and designThe design and implementation of ImageMiner, a software platform for performing comparative analysis of expression patterns in imaged microscopy specimens such as tissue microarrays (TMAs), is described. ImageMiner is a federated system of services that provides a reliable set of analytical and data management capabilities for investigative research applications in pathology. It provides a library of image processing methods, including automated registration, segmentation, feature extraction, and classification, all of which have been tailored, in these studies, to support TMA analysis. The system is designed to leverage high-performance computing machines so that investigators can rapidly analyze large ensembles of imaged TMA specimens. To support deployment in collaborative, multi-institutional projects, ImageMiner features grid-enabled, service-based components so that multiple instances of ImageMiner can be accessed remotely and federated.
机译:目的和设计描述了ImageMiner的设计和实现,ImageMiner是用于对成像显微标本(例如组织微阵列(TMA))中的表达模式进行比较分析的软件平台。 ImageMiner是一个联合服务系统,可为病理学的研究应用程序提供可靠的分析和数据管理功能。它提供了一个图像处理方法库,包括自动配准,分割,特征提取和分类,所有这些方法在这些研究中都经过了定制,以支持TMA分析。该系统旨在利用高性能计算机器,以便研究人员可以快速分析成像的TMA标本的大型集合。为了支持在多机构协作项目中的部署,ImageMiner具有基于网格的,基于服务的组件,因此可以远程访问并联合多个ImageMiner实例。

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