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首页> 美国卫生研究院文献>Journal of Alternative and Complementary Medicine >Gene Expression Profiles of HIV/AIDS Patients with Qi-Yin Deficiency and Dampness-Heat Retention
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Gene Expression Profiles of HIV/AIDS Patients with Qi-Yin Deficiency and Dampness-Heat Retention

机译：HIV / AIDS气阴两虚湿热证患者的基因表达谱

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>Objectives: Traditional Chinese Medicine (TCM) applied in the clinic as a complementary and alternative therapy has helped improve immunity and reduce side effects and symptomatic treatment in patients with HIV/AIDS. However, the mechanisms of TCM syndromes are not clear. Transcriptomics enables the study of such TCM syndromes.>Design: This study compared the messenger RNA (mRNA) expressions of healthy persons and patients with HIV/AIDS who had two common TCM syndromes, qi-yin deficiency and dampness-heat retention, to find the difference in HIV/AIDS with TCM syndromes.>Results: Comparison with healthy persons identified 113 mRNAs—41 enhanced and 72 decreased—in the qi-yin deficiency group. Additionally, 76 mRNAs were found in the dampness-heat retention group: 14 increased and 62 decreased. Functional genetic analysis of the mRNAs indicated that two TCM syndromes were correlated with cell apoptosis, immunoinflammatory responses, and lymphocyte activation. Differentially expressed mRNAs in the qi-yin deficiency group were obviously associated with cellular activity, communication, protein localization, cellular ion homeostasis, and regulation of cell motion, whereas mRNAs in the dampness-heat retention group were associated with sequence-specific DNA binding, cellular response to stress, and hemopoietic or lymphoid organ development.>Conclusions: These results suggest that the formation of different TCM syndromes in patients with HIV/AIDS were founded on biological transcriptomics, which reveal mechanisms of the formation of these syndromes in HIV/AIDS. Differentially expressed mRNAs in two TCM syndrome groups tended to normalize after TCM intervention, which indicates that TCM might remit symptoms by changing genetic expression.
机译：>目标：在临床中应用的中药（TCM）作为补充疗法和替代疗法，有助于提高免疫力，减少HIV / AIDS患者的副作用和对症治疗。但是，中医证候的机制尚不清楚。转录组学可以研究此类中医证候。>设计：本研究比较了健康人和患有两种常见中医证候（气阴虚湿）的HIV / AIDS患者的信使RNA（mRNA）表达。 >结果：通过与健康人的比较，我们发现在气阴两虚组中有113个mRNA（41个增强而72个下降）。另外，在湿热保持组中发现了76个mRNA：14个增加而62个减少。 mRNA的功能遗传分析表明，两种中医证候与细胞凋亡，免疫炎症反应和淋巴细胞活化有关。气阴两虚组差异表达的mRNAs明显与细胞活性，交流，蛋白质定位，细胞离子稳态和细胞运动的调节有关，而湿热保留组的mRNAs与序列特异性DNA结合有关，细胞对应激的反应，以及造血或淋巴器官的发育。>结论：这些结果表明，HIV / AIDS患者不同中医证候的形成是基于生物转录组学，揭示了其形成机制。这些艾滋病毒/艾滋病综合症。两个中医证候群中差异表达的mRNA在中医干预后趋于正常化，这表明中医可能通过改变基因表达来缓解症状。

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