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Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight

机译：航天中维生素K的状态和航天地面模型

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摘要

Bone loss is a well-documented change during and after long-duration spaceflight. Many types of countermeasures to bone loss have been proposed, including vitamin K supplementation. The objective of this series of studies was to measure change in vitamin K status in response to microgravity under a variety of spaceflight and spaceflight analog (model) conditions, including long-duration spaceflight studies (n = 15), three bed rest studies (n = 15, 49, and 24), and a 14-day saturation dive (n= 6). In crew members who flew 2–6 months on the International Space Station, in-flight and postflight plasma phylloquinone concentrations were unchanged from the preflight mean. Consistent with this finding, urinary γ-carboxyglutamic acid (GLA), a measure of vitamin K-dependent protein turnover, did not change in response to flight. Serum undercarboxylated osteocalcin (%ucOC), a measure of vitamin K function, was generally unchanged in response to flight. Spaceflight findings were corroborated by findings of no changes in phylloquinone, urinary GLA, or %ucOC during or after bed rest in three separate bed rest studies (21–90 days in duration) or after a 14-day saturation dive. The data presented here do not support either a need for vitamin K supplementation during spaceflight or the suggestion of using vitamin K as a bone loss countermeasure in spaceflight. © 2011 American Society for Bone and Mineral Research.
机译：骨丢失是长期飞行期间和之后的有据可查的变化。已经提出了许多类型的骨丢失对策，包括补充维生素K。该系列研究的目的是测量在各种航天和航天模拟（模型）条件下，微重力引起的维生素K状况变化，包括长期航天研究（n = 15），三卧床研究（n = 15、49和24），以及14天的饱和潜水（n = 6）。在国际空间站飞行2-6个月的机组人员中，飞行中和飞行后血浆中的叶醌浓度与飞行前平均值相同。与该发现一致的是，尿γ-羧基谷氨酸（GLA）（一种测量维生素K依赖性蛋白质更新的指标）并未响应飞行而改变。血清欠羧化骨钙素（％ucOC）（一种测量维生素K功能的量）通常对飞行有反应。在三项单独的卧床研究（持续时间21-90天）或14天的饱和潜水之后，卧床休息期间或之后，叶绿醌，尿液中的GLA或％ucOC没有变化，从而证实了太空飞行的发现。此处提供的数据不支持在太空飞行期间补充维生素K或建议在太空飞行中使用维生素K作为骨丢失对策。 ©2011美国骨骼和矿物质研究学会。

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