• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Journal of Endourology >Magnetic Resonance Imaging/Transrectal Ultrasonography Fusion Prostate Biopsy Significantly Outperforms Systematic 12–Core Biopsy for Prediction of Total Magnetic Resonance Imaging Tumor Volume in Active Surveillance Patients
【2h】

Magnetic Resonance Imaging/Transrectal Ultrasonography Fusion Prostate Biopsy Significantly Outperforms Systematic 12–Core Biopsy for Prediction of Total Magnetic Resonance Imaging Tumor Volume in Active Surveillance Patients

机译：磁共振成像/经直肠超声检查融合前列腺活检显着优于系统性12芯活检可预测主动监护患者的总磁共振成像肿瘤体积

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

>Objective: To correlate the highest percentage core involvement (HPCI) and corresponding tumor length (CTL) on systematic 12-core biopsy (SBx) and targeted magnetic resonance imaging/transrectal ultrasonography (MRI/TRUS) fusion biopsy (TBx), with total MRI prostate cancer (PCa) tumor volume (TV).>Patients and Methods: Fifty patients meeting criteria for active surveillance (AS) based on outside SBx, who underwent 3.0T multiparametric prostate MRI (MP–MRI), followed by SBx and TBx during the same session at our institution were examined. PCa TVs were calculated using MP-MRI and then correlated using bivariate analysis with the HPCI and CTL for SBx and TBx.>Results: For TBx, HPCI and CTL showed a positive correlation (R2=0.31, P<0.0001 and R2=0.37, P<0.0001, respectively) with total MRI PCa TV, whereas for SBx, these parameters showed a poor correlation (R2=0.00006, P=0.96 and R2=0.0004, P=0.89, respectively). For detection of patients with clinically significant MRI derived tumor burden greater than 500 mm3, SBx was 25% sensitive, 90.9% specific (falsely elevated because of missed tumors and extremely low sensitivity), and 54% accurate in comparison with TBx, which was 53.6% sensitive, 86.4% specific, and 68% accurate.>Conclusions: HPCI and CTL on TBx positively correlates with total MRI PCa TV, whereas there was no correlation seen with SBx. TBx is superior to SBx for detecting tumor burden greater than 500 mm3. When using biopsy positive MRI derived TVs, TBx better reflects overall disease burden, improving risk stratification among candidates for active surveillance.
机译：>目的：将系统性12芯活检（SBx）和靶向磁共振成像/经直肠超声检查（MRI / TRUS）融合活检的最高核心累及率（HPCI）和相应的肿瘤长度（CTL）相关联（TBx），其总MRI前列腺癌（PCa）肿瘤体积（TV）。>患者和方法：接受了基于外部SBx的50例符合主动监测（AS）标准的患者，他们接受了3.0T多参数前列腺在我们机构的同一次会议中，检查了MRI（MP–MRI），然后检查了SBx和TBx。使用MP-MRI计算PCa电视，然后使用双变量分析将SBx和TBx与HPCI和CTL关联。>结果：对于TBx，HPCI和CTL显示正相关（R 2 < /sup>=0.31，P<0.0001和R 2 = 0.37，P <0.0001）与全部MRI PCa TV相比，而对于SBx，这些参数的相关性较差（R 2 = 0.00006，P = 0.96和R 2 = 0.0004，P = 0.89）。对于检测具有临床意义的MRI导致的肿瘤负荷大于500µmm 3 的患者，SBx的敏感性为25％，特异性为90.9％（由于遗漏肿瘤且敏感性极低而错误升高），准确度为54％与TBx相比，灵敏度为53.6％，特异性为86.4％，准确度为68％。>结论： TBx上的HPCI和CTL与MRI PCa TV总体呈正相关，而与SBx则没有相关性。 TBx在检测大于500 mm 3 的肿瘤负荷方面优于SBx。使用MRI活检阳性的电视时，TBx更好地反映了总体疾病负担，从而改善了进行主动监测的候选人之间的风险分层。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号